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10 July 2017
Amid increasingly extreme projections for future sea-level rise, concerns are mounting that policymakers are struggling to keep abreast of fast-paced scientific developments. To ease this burden and increase the accessibility of published research, we have compiled an editor-curated collection of the most recent sea-level rise articles published at Nature Communications.
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An interdisciplinary collection of recent research on complex systems.
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Do you love science but feel that a career at the bench isn’t enough to sate your desire to learn more about the natural world? We are looking for someone like you to join our editorial team in London, New York, Shanghai or Berlin.
09 August 2017
Lipopolysaccharides (LPS) are synthesized at the periplasmic side of the inner membrane of Gram-negative bacteria and are then extracted by the LptB2FG complex during the first step of LPS transport to the outer membrane. Here the authors present the LptB2FG structure, which supports an alternating lateral access mechanism for LPS extraction.
Haohao Dong, Zhengyu Zhang, Xiaodi Tang, Neil G. Paterson&&&Changjiang Dong
09 August 2017
Gene networks evolve by transcription factor (TF) duplication and divergence of their binding site specificities, but little is known about the global constraints at play. Here, the authors study the coevolution of TFs and binding sites using a biophysical-evolutionary approach, and show that the emerging complex fitness landscapes strongly influence regulatory evolution with a role for crosstalk.
Tamar Friedlander, Roshan Prizak, Nicholas H. Barton&&&Ga?per Tka?ik
09 August 2017
Many strains of Plasmodium differ in virulence, but factors that control these distinctions are not known. Here the authors comparatively map virulence loci using the offspring from a P. yoelii YM and N67 genetic cross, and identify a putative HECT E3 ubiquitin ligase that may explain the variance.
Sethu C. Nair, Ruixue Xu, Sittiporn Pattaradilokrat, Jian Wu, Yanwei Qi, Martine Zilversmit, Sundar Ganesan, Vijayaraj Nagarajan, Richard T. Eastman, Marlene S. Orandle, John C. Tan, Timothy G. Myers, Shengfa Liu, Carole A. Long, Jian Li&&&Xin-zhuan Su
09 August 2017
Planktonic bacteria are untethered to surfaces or to each other, and thus are expected to move independently when at low cell densities. Here Sretenovic et al. show, using optical tweezers, that bacteria in dilute suspensions are mechanically coupled and show long-range correlated motion.
Simon Sretenovic, Biljana Stojkovi?, Iztok Dogsa, Rok Kostanj?ek, Igor Poberaj&&&David Stopar
09 August 2017
Yeoh et al. study root microbiomes of different plant phyla across a tropical soil chronosequence. They confirm that soil type is the primary determinant of root-associated bacterial communities, but also observe a clear correlation with plant phylogeny and define a core root microbiome at this site.
Yun Kit Yeoh, Paul G. Dennis, Chanyarat Paungfoo-Lonhienne, Lui Weber, Richard Brackin, Mark A. Ragan, Susanne Schmidt&&&Philip Hugenholtz
09 August 2017
The origin of interface charge transfer and electron-phonon coupling in single unit-cell FeSe on SrTiO3 remains elusive. Here, Zhang et al. report strengthened Ti-O bond and band bending at the FeSe/SrTiO3 interface, which leads to several important processes.
Huimin Zhang, Ding Zhang, Xiaowei Lu, Chong Liu, Guanyu Zhou, Xucun Ma, Lili Wang, Peng Jiang, Qi-Kun Xue&&&Xinhe Bao
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06 March 2018 &
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Proteomics in Cell Biology and Disease Mechanisms
28 February 2018 &
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The 4th Conference on New Advances in Condensed Matter Physics (NACMP 2017)
24 September 2017 &
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01 December 2017 &
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点击数:加入时间:Nature Communication:科学家们找到新的治疗癌症的方法
（图片摘自）
日 讯 /生物谷BIOON/ --科学家们发现一种能够杀死癌细胞的新方法，即利用机体自身的细胞清除功能。来自澳大利亚研究者们通过激活细胞内部一种叫做"BAK"的蛋白质，从而促使癌细胞死亡。
"我们发现了一种全新的激活Bak蛋白的方式，这十分令人兴奋"，来自Walter and Eliza Hall医学研究所的研究者之一Ruth Kluck说道。
Bak是我们体内正常情况下介导细胞凋亡的关键蛋白。凋亡作用能够帮助清除我们不需要的细胞，但一旦这一蛋白失去功能，癌细胞就会不受控制地增殖。
通过对Bak蛋白三维结构的分析，该研究组找到了一种能够特异性结合Bak蛋白并将其激活的抗体。之后他们利用该抗体进行了功能学检测。
"目前我们对如何激活Bak蛋白并用于治疗癌症等凋亡异常导致的疾病抱有极大的兴趣"，Kluck说道："这一发现给与我们新的治疗该类疾病的思路"。
科学家们早已知道一类叫做BH-3的蛋白质家族能够激活Bak，但如今他们找到了一类新的激活方式。下一步，他们计划将这类抗体制作成药物导入细胞内部，并在活体水平进行检测。
该类药物同样适用于治疗自体免疫疾病。在自体免疫病发病过程中，凋亡功能的失效导致免疫细胞异常地攻击机体自身的细胞组织。因此，Bak能够对这些细胞同样进行杀伤。
这是癌症研究最为激动人心的时代，科学家们在传统的放疗与化疗之外，正一点点地开发新的癌症疗法。
比如，我们开发出能够将化学药物输送到脑部的纳米颗粒，以及我们对癌症的认识正在一步步地加深。希望包括Bak抗体在内，这些新的研究成果能够有效地帮助治疗癌症。
相关结果发表在最近的《nature communication》杂志上。（生物谷）
doi:10.1038/ncomms11734
Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies
Sweta Iyer, Khatira Anwari, Amber E. Alsop, Wai Shan Yuen, David C. S. Huang, John Carroll, Nicholas A. Smith,Brian J. Smith,Grant Dewson & Ruth M. Kluck
During apoptosis, Bak and Bax are activated by BH3-only proteins binding to the α2-α5 Bax is also activated via a rear pocket. Here we report that antibodies can directly activate Bak and mitochondrial Bax by binding to the α1-α2 loop. A monoclonal antibody (clone 7D10) binds close to α1 in non-activated Bak to induce conformational change, oligomerization, and cytochrome c release. Anti-FLAG antibodies also activate Bak containing a FLAG epitope close to α1. An antibody (clone 3C10) to the Bax α1-α2 loop activates mitochondrial Bax, but blocks translocation of cytosolic Bax. Tethers within Bak show that 7D10 binding directly extricates α1; a structural model of the 7D10 Fab bound to Bak reveals the formation of a cavity under α1. Our identification of the α1-α2 loop as an activation site in Bak paves the way to develop intrabodies or small molecules that directly and selectively regulate these proteins.
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