Diclazepam (Ro5-3448), also known as chlorodiazepam and 2'-chloro-diazepam, is a
of . It was first synthesized by
and his team at Hoffman-La Roche in 1960. It is not currently approved for use as a medication, but rather sold as an unscheduled substance. Efficacy and safety have not been tested in humans.
In animal models, its effects are similar to diazepam, possessing long-acting , , , , , and
properties.[]
Metabolism of this compound has been assessed, revealing diclazepam has an approximate elimination half-life of 42 hours and undergoes N-demethylation to , which can be detected in urine for 6 days following administration of the parent compound. Other metabolites detected were
which were detectable in urine for 19 and 11 days, respectively, indicating
enzymes occurring concurrently with N-demethylation.
In the UK, diclazepam has been classified as a
by the May 2017 amendment to
along with several other benzodiazepine drugs.
(Nordiclazepam)
(4'-Chlorodiazepam)
Moosmann B, Bisel P, Auw?rter V (July–August 2014). . Drug Testing and Analysis. 6 (7–8): 757–63. :.
, "Amino substituted benzophenone oximes and derivatives thereof"
Madeleine Pettersson B Anders H Therese H Olof Beck (2016). . Drug Testing and Analysis. :.
H?iseth, G Tuv, Silja S Karinen, Ritva (2016). . Forensic Science International. 268: 35–38. :.
Manchester, Kieran R.; Maskell, Peter D.; Waters, Laura (2018). . Drug Testing and Analysis. :.
Bareggi SR, Truci G, Leva S, Zecca L, Pirola R, Smirne S (1988). "Pharmacokinetics and bioavailability of intravenous and oral chlordesmethyldiazepam in humans". European Journal of Clinical Pharmacology. 34 (1): 109–112. :.中文名称：7-氯-5-(2-氯苯基)-1,3-二氢-1-甲基-2H-1,4-苯并二氮杂卓-2-酮
英文名称：2-chlorodiazepam
发布时间：
产品属性：
产品名称: 7-氯-5-(2-氯苯基)-1,3-二氢-1-甲基-2H-1,4-苯并二氮杂卓-2-酮产品英文名称: 2-chlorodiazepam产品价格: 11有效期: 一个月品牌: crovell产地: 石家庄保存条件: dry and ventilate纯度规格: 99%产品类别: 医药中间体
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Product Name:DiclazepamSynonyms:2-chlorodiazepam;1-Methyl-7-chloro-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepine-2-one;1-Methyl-7-chloro-5-(2-chlorophenyl)-1H-1,4-benzodiazepine-2(3H)-one;7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one;o-Chlorodiazepam;Ro 5-3448;DiclazepaM;2H-1,4-Benzodiazepin-2-one,7-chloro-5-(2-chlorophenyl)-1,3-dihydro-1-Methyl-CAS:MF:C16H12Cl2N2OMW:319.19EINECS:Mol File:
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