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HAL Id : hal-, version 1
Natacha Fourny, Carole Lan, Frank Kober, Monique Bernard, Martine Desrois. Modification of cardiac morphology was associated with impaired myocardial sensitivity to ischemia-reperfusion injury in a diet-induced metabolic syndrome model. 53rd Annual Meeting of the European Association for the Study of Diabetes (EASD), Sep 2017, Lisbon/PT, France. 60 Supplement 1 (S1), pp.S547--S547, 2017, Diabetologia. .
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2005年度 秋季學術大會 ?文集,
8-143 (6 pages)
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Gas valve for domestic use is used for flow control of LPG(Liquefied Petroleum Gas) or LNG(Liquefied Natural Gas) of which pressure is about 200mmH?O(?0.0196 [bar]). Currently, two kinds of valves such as rotary type and button type are widely used in many applications. But, these valves have some problems that they are not controllable and reliable. Piezo actuation combined with modern microelectronics provides a reliable, quiet, low energy, infinitely adjustable gas valve. In this paper, gas valve using piezo actuator which are bimorph and a circle type was studied. Also, Prototype for gas valve was manufactured and characteristics of the prototype gas valve were analyzed.
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Ascorbic acid (AsA) is unevenly distributed throughout all body cells and fluids. Multiactivities of AsA in many biological systems and in various scientific fields were reported. In this study we aimed to clarify the inhibitory action of high concentration of AsA on the cell growth in 3T6 fibroblasts. The cells were exposed to AsA at various concentration. It showed that 3T6 fibroblasts were dead by the medium which contained AsA at the concentration higher than 0.5 mM. AsA caused hydrogen peroxide (H?O?) generation in a concentration dependent manner. These results suggested that the H?O? was formed in the medium by AsA and acted as a cytotoxic agent. Moreover, it is supposed that hydroxyl radical (?OH) induced from H?O? also acetd as actively cytotoxic agent. This lethal effect of AsA causing the cell death was inhibited by the addition of catalase in the medium. Therefore, addition of AsA at the normal concentrations stimulate cell growth, but excess concentrations of AsA induce cell death.
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dc.contributor
Aalto-yliopisto
dc.contributor
Aalto University
dc.contributor.advisor
Heckman, Caroline
dc.contributor.author
Lepp?, Aino-Maija
dc.date.accessioned
T11:33:29Z
dc.date.available
T11:33:29Z
dc.date.issued
dc.identifier.uri
https://aaltodoc.aalto.fi/handle/537
dc.description.abstract
Cases of secondary myelodysplastic syndrome and secondary acute myeloid leukemia (sMDS/sAML) have increasingly been documented in successfully treated multiple myeloma (MM) patients. Even though pathogenic alterations in MM have been well characterized in the malignant plasma cell fraction, little is known about the mechanisms leading to sMDS/sAML. Also, it is unknown if molecular-level alterations can be detected in the hematopoietic stem and progenitor cells (HSPCs) of MM patients. To characterize the HSPC fraction of MM patients and to identify those that harbor mutations associated with MDS/AML potentially predisposing the patients to the development of secondary diseases, and to study the clonal evolution of MM, next-generation sequencing analysis was performed. The results demonstrate that mutations in genes associated with MDS/AML are frequently detected in the HSPCs of MM patients. In 20 of the 51 HSPC-enriched MM samples, a total of 42 mutations in 23 genes were detected. When the measured variant allele frequency (VAF) in the mutated samples was compared, substantial variance between the patients was noticed. Most of the mutations observed had a low VAF, more specifically 29/42 mutations had a VAF below 10 %. Notably, exposure to alkylating agents during cancer treatment and relapse-status were significantly associated with a higher VAF (both, P&0.01), which is an indication of clonal expansion. Intriguingly, three patients shared mutations specific for MDS/AML in both the HSPC fraction and the plasma cell fraction. Thus, MM patients with detectable MDS/AML associated mutations in HSPCs seem to present two different clonal evolution patterns during MM development: the malignant plasma cell population may arise from a genetically distinct subpopulation as well as from the genetically normal cell population. To conclude, mutations in genes associated with MDS/AML were fairly frequently detected in the HSPCs of MM patients. For some patients, the mutations detected in the HSPCs were also observed in the malignant plasma cells, suggesting that MM can arise from a mutation-bearing, premalignant stem cell progenitor. In the future, it remains of great importance to further the understanding of the difference between malignant and benign clonal hematopoiesis, and to assess whether MDS/AML associated mutations also play a role in the pathogenesis of MM.
dc.format.extent
dc.language.iso
Genomic characterization of hematopoietic stem and progenitor cells in multiple myeloma to study patterns of disease evolution
G2 Pro gradu, diplomity?
dc.contributor.school
Kemian tekniikan korkeakoulu
dc.subject.keyword
multiple myeloma
dc.subject.keyword
secondary myeloid neoplasm
dc.subject.keyword
hematopoietic stem/progenitor cell
dc.subject.keyword
clonal evolution
dc.subject.keyword
next-generation sequencing
dc.identifier.urn
URN:NBN:fi:aalto-
dc.programme.major
Biosystems and Biomaterials Engineering
dc.programme.mcode
dc.type.ontasot
Master's thesis
dc.type.ontasot
Diplomity?
dc.contributor.supervisor
Frey, Alexander
dc.programme
Master’s Programme in Life Science Technologies
dc.location
local.aalto.electroniconly
local.aalto.openaccess
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