OnlineFirst | Molecular Cancer Research
March 09, 2018
Correction | Free Article
Mol Cancer Res DOI:10.86.MCR-18-0186
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Akimitsu Yamada, Masayuki Nagahashi, Tomoyoshi Aoyagi, Wei-Ching Huang, Santiago Lima, Nitai C. Hait, Aparna Maiti, Kumiko Kida, Krista P. Terracina, Hiroshi Miyazaki, Takashi Ishikawa, Itaru Endo, Michael R. Waters, Qianya Qi, Li Yan, Sheldon Milstien, Sarah Spiegel and Kazuaki Takabe
Mol Cancer Res DOI:10.86.MCR-17-0353
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Yifeng Xia, Cheng Zhan, Mingxiang Feng, Mathias Leblanc, Eugene Ke, Narayana Yeddula and Inder M. Verma
Mol Cancer Res DOI:10.86.MCR-17-0576
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Benjamin Yeung, Prem Khanal, Virja Mehta, Laura Trinkle-Mulcahy and Xiaolong Yang
Mol Cancer Res DOI:10.86.MCR-17-0684
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Victoria Peyret, Magalí Nazar, Mariano Martin, Amado A. Quintar, Elmer A. Fernandez, Romina C. Geysels, Cesar Fuziwara, María M. Montesinos, Cristina A. Maldonado, Pilar Santisteban, Edna T. Kimura, Claudia G. Pellizas, Juan P. Nicola and Ana M. Masini-Repiso
Mol Cancer Res DOI:10.86.MCR-17-0433
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Kelly Flentie, Caleb Gonzalez, Brandon Kocher, Yue Wang, Hongtu Zhu, Jayne Marasa and David Piwnica-Worms
Mol Cancer Res DOI:10.86.MCR-17-0603
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Rebecca C. Arend, Angelina I. Londono, Allison M. Montgomery, Haller J. Smith, Zachary C. Dobbin, Ashwini A. Katre, Alba Martinez, Eddy S. Yang, Ronald D. Alvarez, Warner K. Huh, Kerri S. Bevis, J. Michael Straughn, Jacob M. Estes, Lea Novak, David K. Crossman, Sara J. Cooper, Charles N. Landen and Charles A. Leath
Mol Cancer Res DOI:10.86.MCR-17-0594
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Mohamed E. Salem, Alberto Puccini, Axel Grothey, Derek Raghavan, Richard M. Goldberg, Joanne Xiu, W. Michael Korn, Benjamin A. Weinberg, Jimmy J. Hwang, Anthony F. Shields, John L. Marshall, Philip A. Philip and Heinz-Josef Lenz
Mol Cancer Res DOI:10.86.MCR-17-0735
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Michele Pellegrino, Pietro rizza, Alessandra Nigro, Rosangela Ceraldi, Elena Ricci, Ida Perrotta, Saveria Aquila, Marilena Lanzino, Sebastiano Andò, Catia Morelli and Diego Sisci
Mol Cancer Res DOI:10.86.MCR-17-0662
March 06, 2018
Rapid Impact
Guillaume P. Andrieu and Gerald V. Denis
Mol Cancer Res DOI:10.86.MCR-17-0568
Oncogenes and Tumor Suppressors
Mei Ding, Theodorus H. Van der Kwast, Ravi N. Vellanki, Warren D. Foltz, Trevor D. McKee, Nahum Sonenberg, Pier P. Pandolfi, Marianne Koritzinsky and Bradly G. Wouters
Mol Cancer Res DOI:10.86.MCR-17-0696
Cell Death and Survival
Jeffrey S. Damrauer, Stephanie N. Phelps, Katie Amuchastegui, Ryan Lupo, Nathaniel W. Mabe, Andrea Walens, Benjamin R. Kroger and James V. Alvarez
Mol Cancer Res DOI:10.86.MCR-17-0492
Metabolism
Dieter Henrik Heiland, Annette Gaebelein, Melanie B?rries, Jakob W?rner, Nils Pompe, Pamela Franco, Sabrina Heynckes, Mark Bartholomae, Darren ?. hAilín, Maria Stella Carro, Marco Prinz, Stefan Weber, Irina Mader, Daniel Delev and Oliver Schnell
Mol Cancer Res DOI:10.86.MCR-17-0680
Signal Transduction
Kisha A. Scarlett, El-Shaddai Z. White, Christopher J. Coke, Jada R. Carter, Latoya K. Bryant and Cimona V. Hinton
Mol Cancer Res DOI:10.86.MCR-16-0481
February 28, 2018
DNA Damage and Repair
Kirsten M. Tracy, Coralee E. Tye, Prachi N. Ghule, Heidi L.H. Malaby, Jason Stumpff, Janet L. Stein, Gary S. Stein and Jane B. Lian
Mol Cancer Res DOI:10.86.MCR-17-0548
Signal Transduction
Thu H. Truong, Hsiangyu Hu, Nuri A. Temiz, Kyla M. Hagen, Brian J. Girard, Nicholas J. Brady, Kathryn L. Schwertfeger, Carol A. Lange and Julie H. Ostrander
Mol Cancer Res DOI:10.86.MCR-17-0598
Oncogenes and Tumor Suppressors
Linlin Shao, Zheng Chen, Dunfa Peng, Mohammed Soutto, Shoumin Zhu, Andreia Bates, Shutian Zhang and Wael El-Rifai
Mol Cancer Res DOI:10.86.MCR-17-0655
Chromatin, Epigenetics and RNA Regulation
Qian Qian Cai, Yi Wei Dong, Bing Qi, Xiao-Ting Shao, Rong Wang, Zhong Yi Chen, Bao Mei He and Xing Zhong Wu
Mol Cancer Res DOI:10.86.MCR-17-0527
February 27, 2018
DNA Damage and Repair | AuthorChoice
Adrian Frick, Vineeta Khare, Gregor Paul, Michaela Lang, Franziska Ferk, Siegfried Knasmüller, Andrea Beer, Georg Oberhuber and Christoph Gasche
Mol Cancer Res DOI:10.86.MCR-17-0451
Chromatin, Epigenetics and RNA Regulation | AuthorChoice
Houliang Deng, Jianming Zeng, Ting Zhang, Longcai Gong, Hongjie Zhang, Edwin Cheung, Chris Jones and Gang Li
Mol Cancer Res DOI:10.86.MCR-17-0460
Signal Transduction | AuthorChoice
Nicola Aceto, Aditya Bardia, Ben S. Wittner, Maria C. Donaldson, Ryan O’Keefe, Amanda Engstrom, Francesca Bersani, Yu Zheng, Valentine Comaills, Kira Niederhoffer, Huili Zhu, Olivia Mackenzie, Toshi Shioda, Dennis Sgroi, Ravi Kapur, David T. Ting, Beverly Moy, Sridhar Ramaswamy, Mehmet Toner, Daniel A. Haber and Shyamala Maheswaran
Mol Cancer Res DOI:10.86.MCR-17-0480
Oncogenes and Tumor Suppressors
Tsuyoshi Hasegawa, Garrison J. Glavich, Mary Pahuski, Aleena Short, O. John Semmes, Lifang Yang, Vitold Galkin, Richard Drake and Aurora Esquela-Kerscher
Mol Cancer Res DOI:10.86.MCR-17-0321
February 26, 2018
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Shankha Subhra Chatterjee, Mayukh Biswas, Liberalis Debraj Boila, Debasis Banerjee and Amitava Sengupta
Mol Cancer Res DOI:10.86.MCR-17-0493
February 20, 2018
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Shirin Ilkhanizadeh, Hanna Sabelstr?m, Yekaterina A. Miroshnikova, Aaron Frantz, Wen Zhu, Aurora Idilli, Johnathon N Lakins, Christin Schmidt, David Quigley, Trenten Fenster, Edith Yuan, Jacqueline R Trzeciak, Supna Saxena, Olle R. Lindberg, Janna Mouw, Jason A Burdick, Sergey Magnitsky, Mitchel S Berger, Joanna J Phillips, Daniele Arosio, Dandan Sun, Valerie M. Weaver, William A. Weiss and Anders I Persson
Mol Cancer Res DOI:10.86.MCR-17-0413
February 16, 2018
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Lucy X. Chen, Cintli C. Morales-Alcala and Natalia A. Riobo-Del Galdo
Mol Cancer Res DOI:10.86.MCR-17-0597
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Laura W. Bowers, Emily L. Rossi, Shannon B. McDonell, Steven S. Doerstling, Subreen A. Khatib, Claire G. Lineberger, Jody E. Albright, Xiaohu Tang, Linda A. deGraffenried and Stephen D. Hursting
Mol Cancer Res DOI:10.86.MCR-17-0508
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Jonas Blaes, Carina M. Thomé, Philipp-Niclas Pfenning, Petra Rübmann, Felix Sahm, Antje Wick, Theresa Bunse, Torsten Schmenger, Jaromir Sykora, Andreas von Deimling, Benedikt Wiestler, Christian Merz, Manfred Jugold, Uwe Haberkorn, Amir Abdollahi, Jürgen Debus, Christian Gieffers, Claudia Kunz, Martin Bendszus, Michael Kluge, Michael Platten, Harald Fricke, Wolfgang Wick and Dieter Lemke
Mol Cancer Res DOI:10.86.MCR-17-0563
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Jacqueline R. Ha, Ryuhjin Ahn, Harvey W. Smith, Valerie Sabourin, Steven H?bert, Eduardo Cepeda Ca?edo, Young Kyuen Im, Claudia Kleinman, William J. Muller and Josie Ursini-Siegel
Mol Cancer Res DOI:10.86.MCR-17-0623
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Udit Singhal, Yugang Wang, James Henderson, Yashar S. Niknafs, Yuanyuan Qiao, Amy Gursky, Alexander Zaslavsky, Jae-Seung Chung, David C. Smith, R. Jeffrey Karnes, S. Laura Chang, Felix Y. Feng, Ganesh S. Palapattu, Russell S. Taichman, Arul M. Chinnaiyan, Scott A. Tomlins and Todd M. Morgan
Mol Cancer Res DOI:10.86.MCR-17-0539
February 09, 2018
Rapid Impact | AuthorChoice | AUTHOR MANUSCRIPT
Zhifen Yang, Jing Zhang, Dadi Jiang, Purvesh Khatri, David E. Solow-Cordero, Diego A.S. Toesca, Constantinos Koumenis, Nicholas C. Denko, Amato J. Giaccia, Quynh-Thu Le and Albert C. Koong
Mol Cancer Res DOI:10.86.MCR-17-0307
January 29, 2018
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Ken-ichi Takayama, Takashi Suzuki, Tetsuya Fujimura, Satoru Takahashi and Satoshi Inoue
Mol Cancer Res DOI:10.86.MCR-17-0471
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Lu Wang, Yue Meng, Jian-Jun Xu and Qing-Yun Zhang
Mol Cancer Res DOI:10.86.MCR-17-0519
January 12, 2018
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Tsuyoshi Morita and Kenichiro Hayashi
Mol Cancer Res DOI:10.86.MCR-17-0715
November 22, 2017
Oncogenes and Tumor Suppressors
Balabhadrapatruni V.S.K. Chakravarthi, Darshan S. Chandrashekar, Sumit Agarwal, Sai Akshaya Hodigere Balasubramanya, Satya S. Pathi, Moloy T. Goswami, Xiaojun Jing, Rui Wang, Rohit Mehra, Irfan A. Asangani, Arul M. Chinnaiyan, Upender Manne, Guru Sonpavde, George J. Netto, Jennifer Gordetsky and Sooryanarayana Varambally
Mol Cancer Res DOI:10.86.MCR-17-0230Extracellular vesicle-mediated transfer of long non-coding RNA ROR modulates chemosensitivity in human hepatocellular cancer - ScienceDirect
Download PDFDownloadExport JavaScript is disabled on your browser. Please enable JavaScript to use all the features on this page., 2014, Pages 458-467open accessAuthor links open overlay panelShow moreHighlightsoSelected long non-coding RNA are aberrantly expressed in hepatocellular cancers.olinc-ROR is a highly upregulated lncRNA that is expressed in response to TGFβ.olinc-ROR contributes to chemoresistance of HCC cells.oIntercellular transfer of linc-ROR occurs within extracellular vesicles.AbstractHepatocellular cancers (HCC) are highly resistant to chemotherapy. TGFβ has been associated with chemoresistance in some human cancers but the mechanisms involved are unknown. We explored how TGFβ might contribute to altered responses to therapy by assessing the involvement and mechanistic contribution of extracellular vesicle long non-coding RNA (lncRNA) in mediating TGFβ-dependent chemoresistance. TGFβ reduced the sensitivity of HCC cells to sorafenib or doxorubicin and altered the release of both extracellular vesicles and of selected lncRNA within these vesicles. Amongst these, lincRNA-ROR (linc-ROR), a stress-responsive lncRNA was highly expressed in HCC cells and enriched within extracellular vesicles derived from tumor cells. Incubation with HCC-derived extracellular vesicles increased linc-ROR expression and reduced chemotherapy-induced cell death in recipient cells. Sorafenib increased linc-ROR expression in both tumor cells and extracellular vesicles, whereas siRNA to linc-ROR increased chemotherapy-induced apoptosis and cytotoxicity. Tumor-initiating cells that express CD133 have an increased resistance to therapy. TGFβ increased expression of CD133+ cells and colony growth in limiting dilution assays, both of which were attenuated by linc-ROR knockdown. These data provide mechanistic insights into primary chemoresistance in HCC by showing that: (a) TGFβ selectively enriches linc-RoR within extracellular vesicles, which has a potential role in intercellular signaling in response to TGFβ; (b) expression and enrichment of linc-ROR during chemotherapeutic stress plays a functional rol and (c) the effects of TGFβ on chemoresistance in HCC may involve linc-RoR-dependent effects on tumor-initiating cells. These findings implicate extracellular vesicle lncRNA as mediators of the chemotherapeutic response, and support targeting linc-ROR to enhance chemosensitivity in HCC.AbbreviationsEVextracellular vesicleHCChepatocellular carcinomamiRNAmicroRNAVDvesicle-depletedlncRNAlong non-coding RNAlinc-RORlong intergenic non-coding RNATGFβtransforming growth factor βCTcycle thresholdsiRNAsmall interfering RNAKeywordsLiver cancerChemoresistanceExosomesGene expressionRNA genesRecommended articlesCiting articles (0)The Imprinted H19 LncRNA Antagonizes Let-7 MicroRNAs - ScienceDirect
Download PDFDownloadExport JavaScript is disabled on your browser. Please enable JavaScript to use all the features on this page., 10 October 2013, Pages 101-112Author links open overlay panelShow moreopen archiveHighlightsoH19 lncRNA harbors both canonical and noncanonical binding sites for let-7 microRNAsoH19 lncRNA acts as a natural sponge for let-7oH19 depletion causes accelerated muscle differentiation in vitroSummaryAbundantly expressed in fetal tissues and adult muscle, the developmentally regulated H19 long noncoding RNA (lncRNA) has been implicated in human genetic disorders and cancer. However, how H19 acts to regulate gene function has remained enigmatic, despite the recent implication of its encoded miR-675 in limiting placental growth. We noted that vertebrate H19 harbors both canonical and noncanonical binding sites for the let-7 family of microRNAs, which plays important roles in development, cancer, and metabolism. Using H19 knockdown and overexpression, combined with in vivo crosslinking and genome-wide transcriptome analysis, we demonstrate that H19 modulates let-7 availability by acting as a molecular sponge. The physiological significance of this interaction is highlighted in cultures in which H19 depletion causes precocious muscle differentiation, a phenotype recapitulated by let-7 overexpression. Our results reveal an unexpected mode of action of H19 and identify this lncRNA as an important regulator of the major let-7 family of microRNAs.Recommended articlesCiting articles (0)Endogenous miRNA Sponge lincRNA-RoR Regulates Oct4, Nanog, and Sox2 in Human Embryonic Stem Cell Self-Renewal - ScienceDirect
Download PDFDownloadExport JavaScript is disabled on your browser. Please enable JavaScript to use all the features on this page., 15 April 2013, Pages 69-80Author links open overlay panelShow moreopen archiveSummaryThe embryonic stem cell (ESC) transcriptional and epigenetic networks are controlled by a multilayer regulatory circuitry, including core transcription factors (TFs), posttranscriptional modifier microRNAs (miRNAs), and some other regulators. However, the role of large intergenic noncoding RNAs (lincRNAs) in this regulatory circuitry and their underlying mechanism remains undefined. Here, we demonstrate that a lincRNA, linc-RoR, may function as a key competing endogenous RNA to link the network of miRNAs and core TFs, e.g., Oct4, Sox2, and Nanog. We show that linc-RoR shares miRNA-response elements with these core TFs and that linc-RoR prevents these core TFs from miRNA-mediated suppression in self-renewing human ESC. We suggest that linc-RoR forms a feedback loop with core TFs and miRNAs to regulate ESC maintenance and differentiation. These results may provide insights into the functional interactions of the components of genetic networks during development and may lead to new therapies for many diseases.Graphical AbstractHighlights? A lincRNA-RoR function as a key competing endogenous RNA in hESCs ? Linc-RoR prevents core TFs from microRNA-mediated suppression ? Linc-RoR forms a feedback loop with core TFs and microRNAs ? Linc-RoR is a key regulator of hESC self-renewal and differentiationRecommended articlesCiting articles (0)