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你可能喜欢我国中科院上海生命科学研究院计算生物学所在泛素多聚_国家标准物质空间_天涯博客
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　　关键词：标物中心 国家标物中心 北京标物中心 中国标物中心 标准物质网站 国家标准物质网站摘& 要：中科院上海生命科学研究院计算生物学所研究组长Frauke Graeter博士和夏飞博士利用分子模拟的方法，理论研究了泛素多聚体折叠过程以及中间体的性质，并提出多聚体中单体间的相互作用将导致中间体的产生，而这些稳定的中间体通过两个相邻单体间交换相同的二级结构形成。理论计算的结果表明，去折叠后，这些中间体将产生2到30纳米的距离分布，这与实验观测的结果一致，进一步的动力学分析也与实验相符。该理论研究为泛素多聚体在外力作用下的折叠中间体提供了新的理论解释。&&& 中科院上海生命科学研究院计算生物学所研究组长Frauke Graeter博士和夏飞博士利用分子模拟的方法，理论研究了泛素多聚体折叠过程以及中间体的性质，并提出多聚体中单体间的相互作用将导致中间体的产生，而这些稳定的中间体通过两个相邻单体间交换相同的二级结构形成。理论计算的结果表明，去折叠后，这些中间体将产生2到30纳米的距离分布，这与实验观测的结果一致，进一步的动力学分析也与实验相符。该理论研究为泛素多聚体在外力作用下的折叠中间体提供了新的理论解释。（国家标物中心）&&& 该研究是与美国马里兰大学的Dave Thirumalai教授合作完成，并在线发表于美国《国家科学院院刊》（PNAS）。（北京标物中心）&&& 该工作得到了美国健康研究所、中国国家自然科学基金、计算所奇拉实验室以及德国学术交流中心的支持。（中国标物中心）&&& 最近，新的原子力显微镜实验发现泛素多聚体在外力去折叠后，重折叠的过程中存在大量的稳定的中间体。这些中间体在外力作用下将产生2～30纳米的距离分布，而典型的泛素单体只给出20纳米的距离分布。（标准物质网站）&&& 总结：利用机械力使蛋白质去折叠再诱导其折叠，特别适合用来研究蛋白质在外力作用下的折叠过程。这种方法被广泛应用于原子力显微镜实验（AFM）中对单个生物分子折叠机理的研究。（国家标准物质网站）&&& 更多质量检测、分析测试、化学计量、标准物质相关技术资料请参考 分类： |中科院分子病毒与免疫重点实验室----中国科学院上海巴斯德研究所
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中科院分子病毒与免疫重点实验室
　　一．实验室简介&　　中国科学院分子病毒与免疫重点实验室（）在2010年12月由中科院正式批准成立，依托单位为中科院上海巴斯德研究所。现任学术委员会主任为曹雪涛院士，实验室主任为唐宏研究员，副主任为张晓明、江陆斌、金侠研究员。　 &中科院分子病毒学与免疫学重点实验室坚持“三个面向”，致力于病毒免疫学的基础和应用基础研究，通过原始创新，发现病原-宿主互作新机制，寻找抗病毒感染新靶标，为传染病防控提供新思路与策略。　　二．学术委员会&　　主任：　　曹雪涛（中国医学科学院/协和医科大学 中国工程院院士 教授）　& & 委员：& &&刘小龙（中科院上海生科院生物化学与细胞研究所&研究员）& & 魏于全（四川大学 中国科学院院士 教授）& & 田志刚（中国科技大学 教授）& & 熊思东（苏州大学 教授）& & 黎孟枫（中山大学 教授）& & 陈新文（中科院武汉病毒研究所 研究员）& & 夏宁邵（厦门大学 教授）& & 唐 宏（中科院上海巴斯德研究所 研究员）& & 肖 晖（中科院上海巴斯德研究所 研究员）& & 金 侠（中科院上海巴斯德研究所 研究员）　　三．研究队伍&　　目前实验室根据3个研究方向，共设置了23个研究组。研究组名称如下：&　　1.&病毒学：病毒的急慢性感染机制及相关基础研究&　　&&
组长： 研究员&　　&&
组长：研究员&　　&&
组长： 研究员&　　&&
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组长： 研究员&　　& & 组长： 研究员&　　& & 组长： 研究员&　　&&
组长： 研究员&　　& & 组长： 研究员&　　2.免疫学：阐明病毒与宿主细胞之间的相互作用的分子机制&　　&&
组长： 研究员&　　&& 抗结核免疫与防治研究组 组长：陈维政 研究员&　　&&& 组长： 研究员&　　& & 组长： 正高级工程师&　　& & 组长： 研究员&　　&&
组长： 研究员&　　& & 组长： 研究员&　　& & 组长： 研究员&　　3.疫苗学基础研究与应用基础研究&　　&&
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组长： 研究员&　　& & 组长： 研究员&　　&&
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组长： 研究员&　　& & 组长： 研究员&　　　　四．研究成果&　　2013&　　1.Liu Q, Huang X, Ku Z, Wang T, Liu F, Cai Y, Li D, Leng Q, Huang Z*. J Virol Methods. ):127-31.Epub 2012 Oct 6.　　2.Hu W, Chen A, Miao Y, Xia S, Ling Z, Xu K, Wang T, Xu Y, Cui J, Wu H, Hu G, Tian L, Wang L, Shu Y, Ma X, Xu B, Zhang J, Lin X*, Bian C*, Sun B*.
Virology. 2013 Jan 20;435(2):320-8 Epub 2012 Oct 16　　3.Xia T, Lévy L, Levillayer F, Jia B, Li G, Neuveut C, Buendia MA, Lan K*, Wei Y*.
J Biol Chem. 2013 Jan 18;288(3):1785-94. Epub 2012 Dec 4.　　4.Liu L, Wang W, Yang L, Ren H, Kimata JT, Zhou P*.
J Virol. ):. Epub 2012 Nov 14.　　5., , , , , , , , , , , , , , *, *, *. Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock. Cell Res.):201-12.　　6.Qian M, Hu H, Zuo T, Wang G, Zhang L, Zhou P*. J Virol. ):3571-7.　　7.Zhang J, Chen C, Hou X, Gao Y, Lin F, Yang J, Gao Z, Pan L, Tao L, Wen C, Yao Z, Tsun A, Shi G*, Li B*.
J Biol Chem. 2013 Feb 10. [Epub ahead of print]　　8.Chen Z, Luo X, Lu Y, Zhu T, Wang J, Tsun A*, Li B*.
Int Immunopharmacol. 2013 Feb 14. .　　9.Ku Z, Ye X, Huang X, Cai Y, Liu Q, Li Y, Su Z, Huang Z*
PLoS One. ):e57601. Epub 2013 Feb 22.　　10.Shi J, Huang X, Liu Q, Huang Z*. Vaccine. 2013 Mar 13.　　11.Cai Y, Liu Q, Huang X, Li D, Ku Z, Zhang Y*, Huang Z*.
Vaccine. 2013 Mar 13.　　12.Liu W, Qin Y, Bai L, Lan K, Wang JH*.
Virology. 2013 Mar 16.　　13.Ding Q, Cao X, Lu J, Huang B, Liu YJ, Kato N, Shu HB, Zhong J*.
J Hepatol. ):52-8&　　14.Wang H, Xing Y, Mao L, Luo Y, Kang L, Meng G*.
(communication) Protein Cell. ):259-65. &　　15.Lei G, Chen M, Li H, Niu JL, Wu S, Mao L, Lu A, Wang H, Chen W, Xu B, Leng Q, Xu C, Yang G, An L, Zhu LP, Meng G*. (letter) Cell Res. ):965-8.&　　16.Wang Y, Yang C, Mao K, Chen S, Meng G, Sun B. Protein Cell. ):425-31&　　17.&Li Y, Tsun A, Gao Z, Han Z, Gao Y, Li Z, Lin F, Wang Y, Wei G, Yao Z, Li B.
J Biol Chem. 2013 May 31;288(22):15537-46&　　18. Zhou P, Wang Z, Yuan X, Zhou C, Liu L, Wan X, Zhang F, Ding X, Wang C, Xiong S, Wang Z, Yuan J, Li Q, Zhang Y.
J Biol Chem. 2013 Jun 14;288(24):17532-43&　　19. Zhai RR, Jiang AP, Wang HB, Ma L, Ren XX, Jiang JF, Wu L, Wei JF, Wang JH.
Virology &2013 Aug 1;442(2):163-72 &　　20. Lu J, Tao W, Li R, Xiang Y, Zhang N, Xiang X, Xie Q, Zhong J*.Virology. 2013 Aug 15;443(1):80-8&　　21.Li HY, Han JF, Qin CF, Chen R.,
Vaccine. 2013 Jul 11;31(32):3281-7 &　　22.Zhang H, Hale BG, Xu K, Sun B*.
Viruses. 2013 Jun 10;5(6):1431-46.&　　23.Wang H, Mao L, Meng G*. Protein Cell. ):565-8.&　　24.Wang G, Zhou F, Buchy P, Zuo T, Hu H, Liu J, Song Y, Ding H, Tsai C, Chen Z, Zhang L, Deubel V, Zhou P. J Infect Dis. ):676-85&&&&　　25.Chen Z, Barbi J, Bu S, Yang HY, Li Z, Gao Y, Jinasena D, Fu J, Lin F, Chen C, Zhang J, Yu N, Li X, Shan Z, Nie J, Gao Z, Tian H, Li Y, Yao Z, Zheng Y, Park BV, Pan Z, Zhang J, Dang E, Li Z, Wang H, Luo W, Li L, Semenza GL, Zheng SG, Loser K, Tsun A, Greene MI, Pardoll DM, Pan F, Li B. Immunity. 2013 August 22; 39(2) :272-85 &　　26.Wei R, Xu L, Zhang N, Zhu K, Yang J, Yang C, Deng C, Zhu Z, De Groot AS, Altmeyer R, Zeng M, Leng Q. Virus Res. ):62-5. &　　27.Shan Z, Han Q, Nie J, Cao X, Chen Z, Yin S, Gao Y, Lin F, Zhou X, Xu K, Fan H, Qian Z, Sun B, Zhong J, Li B, Tsun A.
J Biol Chem. 2013 Dec 6;288(49): &　　28.Qi Y, Xiang Y, Wang J, Qi Y, Li J, Niu J, Zhong J.
Antiviral Res. 2013 Sep 8;100(2):392-398.&&　　29., , , , , , , , , , , , , , , , , , , , , . Nature. 2013 Jul 11;499(. &　　30.Ye X, Ku Z, Liu Q, Wang X, Shi J, Zhang Y, Kong L, Cong Y, Huang Z. . J Virol. ):72-81&　　31.Xu Y, Li H, Chen W, Yao X, Xing Y, Wang X, Zhong J, Meng G.
PLoS One. 2013 Nov 6;8(11):e77955&　　32.Mao L, Zhang L, Li H, Chen W, Wang H, Wu S, Guo C, Lu A, Yang G, An L, Abliz P, Meng G.
Infect Immun. ):882-92. &　　33.Hu W, Chen A, Miao Y, Xia S, Ling Z, Xu K, Wang T, Xu Y, Cui J, Wu H, Hu G, Tian L, Wang L, Shu Y, Ma X, Xu B, Zhang J, Lin X, Bian C, Sun B. Virology. 2013 Jan 20;435(2):320-8. 　　&&　　34.Lu J, Xiang Y, Tao W, Li Q, Wang N, Gao Y, Xiang X, Xie Q, Zhong J. J Virol. ):1484-91.&&&　　35.Zhao C, Su EM, Yang X, Gao Z, Li L, Wu H1, Jiang Y, Su X. . PLoS One. 2013 Dec 19;8(12):e82683. 　　&&　　36.Lyu K, Ding J, Han JF, Zhang Y, Wu XY, He YL, Qin CF, Chen R . J Virol. ):3114-26. 　　&&　　37.Wang Z, Zhu K, Bai W, Jia B, Hu H, Zhou D, Zhang X, Zhang X, Xie Y, Mancini-Bourgine M, Michel ML, Lan K, Deng Q.
J Virol. ):3004-15. 　　&&　　38.Chen W, Xu Y, Li H, Tao W, Xiang Y, Huang B, Niu J, Zhong J, Meng G.
PLoS One. 2014 Jan 6;9(1):e84953.&&　　2012&&　　1.Li YZ, Counor D, Lu P, Liang GD, Huong VT, Nga PT, Loan HT, Sun G, Grandadam M, Butrapet S, Lavergne JP, Flamand M, Yu YX, Solomon T, Buchy P, Deubel V*.A specific and sensitive antigen capture assay for NS1 protein quantitation in Japanese encephalitis virus infection.J Virol Methods. ):8-16. Epub 2011 Jun 15　　2.He Y, Weng L, Li R, Li L, Toyoda T, &Zhong J*.The N-terminal helix α(0) of hepatitis C virus NS3 protein dictates the subcellular localization and stability of NS3/NS4A complex.Virology.&2012 Jan 20;422(2):214-23.　　3.Gao Y, Lin F, Su J, Gao Z, Li Y, Yang J, Deng Z, Liu B, Tsun A, Li B*.Molecular mechanisms underlying the regulation and functional plasticity of FOXP3(+) regulatory T cells.Genes Immun. (Review)):1-13　　4.Wang K, Lu W, Chen J, Xie S, Shi H, Hsu H, Yu W, Xu K, Bian C, Fischer WB, Schwarz W, Feng L*, Sun B* PEDV ORF3 encodes an ion channel protein and regulates virus production..FEBS Lett. 2012 Feb 17;586(4):384-91. Epub 2012 Jan 11.　　5., , , , , *.KSHV-encoded miR-K12-11 attenuates transforming growth factor beta signaling through suppression of SMAD5.J Virol. ):1372-81.　　6.Hongxing Hu, Jarrod Voss, Guoliang Zhang, Philippi Buchy, Teng Zuo, Lulan Wang, Feng Wang, Fan Zhou, Guiqing Wang, Cheguo Tsai, Lesley Calder, Steve J. &Gamblin, Linqi Zhang, Vincent Deubel, Boping Zhou, John J. Skehel and Paul Zhou*. A Human Antibody Recognizing a Conserved Epitope of H5 Hemagglutinin Broadly Neutralizes Highly Pathogenic Avian Influenza H5N1 Viruses.J Virol.):2978-89. Epub 2012 Jan 11.　　7.Xu C, Hu WB, Xu K, He YX, Wang TY, Chen Z, Li TX, Liu JH, Buchy P, Sun B*. Amino acids 473V and 598P of PB1 from an avian origin influenza A virus contribute to polymerase activity especially in mammalian cells.J Gen Virol. &2012 M93(Pt 3):531-40.　　8.Weng L, Kohara M, Wakita T, Shimotohno K, Toyoda T*. Detergent-induced activation of the hepatitis C virus genotype 1b RNA polymerase.Gene.2012 Apr 1;496(2):79-87.Epub 2012 Jan 28.　　9.Jin Y, He Z, Liang D, Zhang Q, Zhang H, Deng Q, Robertson ES, Lan K*.J Virol. ):4956-69. Epub 2012 Feb 29.　　10.Zhou F, Wang G, Buchy P, Cai Z, Chen H, Chen Z, Cheng G, Wan XF, Deubel V, Zhou P*.A Tri-Clade DNA Vaccine Designed on the Basis of a Comprehensive Serologic Study Elicits Neutralizing Antibody Responses against All Clades and Subclades of HPAI H5N1 Viruses.J Virol.):6970-8. Epub 2012 Apr 11　　11.Xiaomin Song, Bin Li, Yan Xiao, Chunxia Chen, Qiang Wang, Yujie Liu, Alan Berezov, Chen Xu,Yayi Gao, Zhiyuan Li, Shiaw-Lin Wu, Zheng Cai,Hongtao Zhang, Barry L. Karger, Wayne W. Hancock, Andrew D. Wells, Zhaocai Zhou*, and Mark I. Greene* Structural and biological features of FOXP3 dimerization relevant to regulatory T Cell function. Cell Rep. 2012 Jun 28;1(6):665-75. Epub 2012 Jun 15.　　12.Li Y, Counor D, Lu P, Duong V, Yu Y, Deubel V*.
Virol J. 2012 Jul 24;9:135.　　13.Yang L, Song Y, Li X, Huang X, Liu J, Ding H, Zhu P, Zhou P*.
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2009 Dec 5;395(1):67-76. Epub 2009 Sep 30.五.实验室年报　　&& & &&六．联系方式　　中国科学院分子病毒与免疫重点实验室　　地址：上海市徐汇区岳阳路320号 生命科学大楼 A209（200031）　　传真：021-　
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