51岁,女。CT影像诊断:胸骨CT后缘影,考虍淋巴结影可能,让临床进一步检查随访。也没开药,怎样治疗。

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Degree centrality in the human functional connectome of basal ganlia stroke patients
目的:采用图论分析方法度中心度(degree centrality,DC),构建并分析基底节区脑梗死患者的人脑功能连接组。材料与方法采集10例脑梗死患者亚急性期和慢性期静息态功能磁共振成像数据,对照组为10例年龄、性别与患者匹配的健康正常志愿者,分别构建每个被试的人脑功能连接组并计算其DC值,提取3个被试组的高DC值节点分布图,并比较各被试组间DC值的差异。结果正常对照组高DC值节点图呈对称分布,位于脑中线后部的楔前叶及后扣带回处、双侧基底节和丘脑;患者分布混乱。与对照组相比,患者亚急性期DC升高的节点位于健侧脑默认网络(default mode network,DMN)后部,降低的节点位于患侧DMN前部,慢性期DC升高的节点位于小脑蚓、健侧楔前叶/扣带回后部;患者两时期比较,亚急性期DC升高的节点位于患侧中央前回、颞上回和缘上回,慢性期DC升高的节点位于小脑蚓、健侧小脑半球和患侧楔前叶。结论基于体素水平分析的度中心度方法,能发现基底节区脑梗死患者人脑功能连接组的异常,并提供有价值的信息。
Abstract:
Objective:Using degree centrality (DC), a gragh theory analysis method to construct and analyze the human functional connectome of basal ganglia stroke patients.Materials and Methods: The resting-state fMRI data of 10 left basal ganglia stroke patients under subacute stage, chronic phase and 10 normal controls were taken, for each scan of every subject, construct the human functional connectome and calculate the DC value, the distribution maps of high DC value nodes were extracted for each group, the intergroup differences were analyzed.Results:The high DC map of the normal control distributed symmetrically, in precuneus/posterior cingulate of the posterior cerebral midline, bilateral basal ganglia and thalamus, the patients' maps distributed in disorder. Compared with normal controls, under subacute stage, DC increased in ipsilateral contralateral default-mode network (DMN), decreased in anterior posterior DMN, under chronic phase, DC increased in vermis, contralateral precuneus/posterior cingulate. Compared between two period of patients, increased DC were found in ipsilateral precentral gyrus, superior temporal gyrus and supramarginal under subacute stage, in vermis, contralateral cerebellum hemisphere and ipsilateral precuneus under chronic phase.Conclusion:At the voxel level, DC can provide valuable information of the abnormal brain functional connectome in basal ganglia stroke patients.
LI Kun-cheng
DUAN Xiang-gong
首都医科大学宣武医院医学影像学部放射科,磁共振成像脑信息学北京重点实验室,北京 100053
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“十二五”国家科技支撑计划课题(编号2012BAI10B04);国家自然科学基金(编号);北京市医院管理局重点医学专业发展计划(编号ZYLX201609)ACKNOWLEDGMENTS This work was part of National Key Technology R&D Program of China during the Twelfth Five-Year Plan Period,National Natural Science Foundation of China,Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support
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11月11日,女51岁做CT。影像诊断:两肪纹理增多;胸骨后缘影孝虑淋巴结影,临床进一步检查随访。
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