EμmiR-155转基因小鼠前B细胞的增值和淋巴母细胞白血病、高分级淋巴瘤的研究_图文_百度文库
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EμmiR-155转基因小鼠前B细胞的增值和淋巴母细胞白血病、高分级淋巴瘤的研究
&&淋巴母细胞白血病、高分级淋巴瘤的研究
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你可能喜欢&&&diffuse large b-cell lymphomas 在 肿瘤学 分类中
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&&&&Prognostic analysis of 51 cases of primary nodal diffuse large B-cell lymphomas
&&&&51例原发性结内弥漫性大B细胞淋巴瘤的预后相关因素分析
&&&&t(14;18)(q32;q21) involving IGH and MALT1 is uncommon in cutaneous MALT lymphomas and primary cutaneous diffuse large B-cell lymphomas
&&&&t(14;18)(q32;q21)累及IGH和MALT1在皮肤MALT淋巴瘤和原发皮肤弥漫性大B细胞淋巴瘤中不常见
&&&&CD_(10) expression and its relationship with cell apoptosis and prognosis of diffuse large B-cell lymphomas
&&&&CD_(10)在弥漫性大B细胞淋巴瘤中的表达及其与细胞凋亡和预后的关系
&&&&Eight of them were peripheral T- cell lymphormas(unspecified)and seven were NK/T cell lymphomas and two were diffuse large B- cell lymphomas.
&&&&组织学类型包括NK/T细胞淋巴瘤7例(41％),外周T细胞淋巴瘤(非特殊型)8例(47％),弥漫性大B细胞淋巴瘤2例(12％)。
&&&&Objective
To explore the prognostic factors of primary nodal diffuse large B-cell lymphomas(N-DLBCL).
&&&&目的　探讨原发性结内弥漫性大B细胞淋巴瘤(N DLBCL)的预后相关因素。
&&&&Clinical Prognostic Analysis of Survivin Expression in Diffuse Large B-Cell Lymphomas
&&&&弥漫大B细胞淋巴瘤survivin表达与临床预后关系探讨
&&&&Characteristics of IgVH Gene Structure in Small B-cell Lymphomas and Diffuse Large B-cell Lymphomas
&&&&小细胞性B-NHL和DLBCL中IgVH基因结构特点的初步研究
In the 20 cases of gastric lymphomas, 10 cases are MALT lym-phomas,9 cases are diffuse large B - cell lymphomas( DLBL) and 1 case mantle cell lymphoma( MCL)
&&&&1．20例胃淋巴瘤包括10例粘膜相关淋巴组织（MALT）淋巴瘤J例弥漫大B细胞淋巴瘤（DLBL人＊例套细胞淋巴瘤（MCL人
&&&&100%(9/9;FCM) and 77.7%(7/9;CM) of diffuse large B-cell lymphomas demonstrated greater than 40% large cells.
&&&&弥散性的大细胞淋巴瘤的大细胞数CM结果100%(9/9),FCM结果77.7%(6/9),超过40%。
&&&&Conclusions CD30-positive LBCL is a clinicopathologic distinctive variant of diffuse large B-cell lymphomas,and may be co-expression of ALK and CD30.
&&&&结论CD30阳性的弥漫性LBCL具有嗜窦性,间变性或为普通性非间变性的组织细胞形态特征,可合并ALK阳性。
查询“diffuse large b-cell lymphomas”译词为用户自定义的双语例句&&&&我想查看译文中含有：的双语例句
为了更好的帮助您理解掌握查询词或其译词在地道英语中的实际用法，我们为您准备了出自英文原文的大量英语例句，供您参考。&&&&&&&&&&&& Bcl
2 protein can protect cells from apoptosis and has relations with the development、transformation and metastasis of tumor.Bcl
2 protein was expressed in 50%-80% of follicular lymphomas、10%-25% of diffuse large B cell lymphomas.Epstein
Barr virus(EBV) has a strong association with B cell lymphomas(BCLs)in immunodeficient patients,but the relationship between EBV and BCLs in immunocompetent patients is rarely eminent.Induction of Bcl
2 expression by EBV in B cells has been... Bcl
2 protein can protect cells from apoptosis and has relations with the development、transformation and metastasis of tumor.Bcl
2 protein was expressed in 50%-80% of follicular lymphomas、10%-25% of diffuse large B cell lymphomas.Epstein
Barr virus(EBV) has a strong association with B cell lymphomas(BCLs)in immunodeficient patients,but the relationship between EBV and BCLs in immunocompetent patients is rarely eminent.Induction of Bcl
2 expression by EBV in B cells has been reported in vitro.EBV may play a role in the pathogenesis of BCLs in immunodeficient patients by inducing Bcl
2 protein expression through LMP
1.Bcl 2蛋白能抑制细胞调亡 ,与肿瘤的发生、转化及转移有关。 50 %～ 80 %的滤泡性淋巴瘤 ,10 %～ 2 5%的弥漫性大细胞性B细胞淋巴瘤中有Bcl 2蛋白的表达。EB病毒 (EBV)与免疫缺陷相关性BCL密切相关 ,而与非免疫缺陷相关性BCL的相关性较小。EBV在体外可以诱导B淋巴细胞表达Bcl 2蛋白。该病毒可能通过LMP 1诱导Bcl 2的表达参与了免疫缺陷相关性BCL的发病 Objective: To study the relationship among Epstein
Barr virus (EBV) infection, p53 protein and p21
expression in intestinal B cell lymphoma. Methods :The immunophenotype of tumor cells, CD20?CD45RA?CD79a for B
cell,CD45RO?CD3 for T cell, p53(DO
7) and p21
for oncogene were studied using some antibodies and immunohistochemistry methods,
in situ hybridyzation was used for detection of EBV encoding small nuclear RNA(EBER). Results:34 cases of intestinal B cell lymphomas often located... Objective: To study the relationship among Epstein
Barr virus (EBV) infection, p53 protein and p21
expression in intestinal B cell lymphoma. Methods :The immunophenotype of tumor cells, CD20?CD45RA?CD79a for B
cell,CD45RO?CD3 for T cell, p53(DO
7) and p21
for oncogene were studied using some antibodies and immunohistochemistry methods,
in situ hybridyzation was used for detection of EBV encoding small nuclear RNA(EBER). Results:34 cases of intestinal B cell lymphomas often located at lower part of lieum and colon, and most of them were single mass with ulcer on its surface. Of 34 cases of intestinal B cell lymphomas ,9 cases(26.5%) were diffuse large B cell lymphomas, 19 cases(55.9%) were marginal zone B cell lymphoma, mucosa associated lymphoid tissue type(MZL
MALT), which were belong to indolent, and 6 cases transferred to high malignancy from indolent
(17.6%). All of the cases were negative for EBV
EBER in situ hybridization. p53 protein were overexpressed in 23 cases (67.6%), near the half cases were high malignancy. 16(47.1%) cases were positive with p21
about 43.8% of which were high malignancy. 15 cases were expressed both with p53 protein and p21
. Conclusion :34 cases of intestinal B cell lymphoma were more often MZL
MALT type, but with high malignancy. EBV results showed that intestinal B cell lymphomas were different from intestinal T cell lymphomas, and they had no relationship with EBV infection.
The expression of p53 protein was higher than that of p21
. The detective rate of co
expression of p53 protein and p21
was high, indicating that p53 protein and p21
play an important role in the formation of intestinal B cell lymphoma.目的 :研究肠道非霍奇金淋巴瘤B细胞型的Epstein Barr(EB)病毒感染、p5 3、p2 1ras基因表达及其相关性。方法 :应用单克隆抗体、免疫组化方法对瘤细胞进行免疫表型研究 ,CD2 0、CD45RA、CD79a鉴定瘤细胞的B细胞分化 ,CD45RO、CD3除外瘤细胞T细胞分化。同时用免疫组化方法 ,检测瘤细胞 p5 3基因表达、p2 1ras基因表达。EB病毒寡核苷酸探针 (EBER)原位杂交 ,观察瘤细胞EB病毒感染情况。结果 :34例肠道B细胞淋巴瘤好发部位为回肠和结肠 ,以单发瘤结节多见 ,常伴有表面溃疡形成。 34例中 ,弥漫性大B细胞淋巴瘤 9例 (2 6 .5 % ) ,19例为惰性的边缘区B细胞淋巴瘤黏膜相关淋巴组织型 (MZL MALT型 ) (5 5 .9% ) ,6例为MZL MALT型伴高度恶性转化(17.6 % )。EBV EBER原位杂交检测 ,全部病例为阴性。p5 3蛋白表达共有 2 3例 ,占全部病例的 6 7.6 % (其中高度恶性占 47.8% ) ;16例有 p2 1ras的表达 ,为 47.1% (其中高度恶性占 43.8% )。有 15例同时检出 p5 ...目的 :研究肠道非霍奇金淋巴瘤B细胞型的Epstein Barr(EB)病毒感染、p5 3、p2 1ras基因表达及其相关性。方法 :应用单克隆抗体、免疫组化方法对瘤细胞进行免疫表型研究 ,CD2 0、CD45RA、CD79a鉴定瘤细胞的B细胞分化 ,CD45RO、CD3除外瘤细胞T细胞分化。同时用免疫组化方法 ,检测瘤细胞 p5 3基因表达、p2 1ras基因表达。EB病毒寡核苷酸探针 (EBER)原位杂交 ,观察瘤细胞EB病毒感染情况。结果 :34例肠道B细胞淋巴瘤好发部位为回肠和结肠 ,以单发瘤结节多见 ,常伴有表面溃疡形成。 34例中 ,弥漫性大B细胞淋巴瘤 9例 (2 6 .5 % ) ,19例为惰性的边缘区B细胞淋巴瘤黏膜相关淋巴组织型 (MZL MALT型 ) (5 5 .9% ) ,6例为MZL MALT型伴高度恶性转化(17.6 % )。EBV EBER原位杂交检测 ,全部病例为阴性。p5 3蛋白表达共有 2 3例 ,占全部病例的 6 7.6 % (其中高度恶性占 47.8% ) ;16例有 p2 1ras的表达 ,为 47.1% (其中高度恶性占 43.8% )。有 15例同时检出 p5 3蛋白和p2 1ras的表达 ,占病例数的 44 .1%。结论 :34例肠道B细胞淋巴瘤以惰性为多见 ,但恶性转化明显。EBV的研究提示肠道B细胞淋巴瘤有别于T细胞淋巴瘤 ,与EBV感染无关。p5 3蛋白的表达高于 p2 1ras,p5 3和 p2 1ras的共同表达检出率较高 ,提示癌基因 p5 3和p2 Objective:Three primary lymphoma of bone are described and a review of the pertinent literature is introduced.Methods:3 patients with primary bone lymphoma were treated,2 patients had surgery as their local treatment and treated with chemotherapy (standard CHOP) followed by local radiotherapy. One patient was treated with chemotherapy and local radiotherapy.Results:3 patients achieved complete remission with no evidence of local recurrence.Conclusion:The majority of primary lymphoma of bone have been more recently... Objective:Three primary lymphoma of bone are described and a review of the pertinent literature is introduced.Methods:3 patients with primary bone lymphoma were treated,2 patients had surgery as their local treatment and treated with chemotherapy (standard CHOP) followed by local radiotherapy. One patient was treated with chemotherapy and local radiotherapy.Results:3 patients achieved complete remission with no evidence of local recurrence.Conclusion:The majority of primary lymphoma of bone have been more recently characterized as diffuse large B
cell lymphomas of primary non
Hodgkin′s lymphoma of bone(PNHLB). Local bone lesions occur any bone of body in many patients with PLB. There are t(3;22)(q27;q11) and high expression of bcl
6 and p53 moleculars which may play a role in the pathogenesis of PNHLB.目的 :报告 3例原发性骨淋巴瘤病例并复习国内外相关文献。方法 :化疗和放疗治疗3例原发性骨淋巴瘤患者。结果 :3例患者均对化疗、放疗敏感 ,并得到完全缓解。结论 :原发性骨淋巴瘤以 B细胞型非霍奇金淋巴瘤多见 ,可侵犯到骨的任何部位 ,通常为局限的溶骨性破坏。 PL B细胞存在 t(3;2 2 ) (q2 7;q11)染色体易位以及 bcl- 2、bcl- 6和 p5 3分子高表达 ,在 PL B病理过程中可能发挥重要作用。&nbsp&&&&&相关查询
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&2008中国知网(cnki)
中国学术期刊(光盘版)电子杂志社【图文】DLBCL, FL 恶性淋巴瘤_百度文库
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WHO-EORTC classification for cutaneous lymphomas
汇报者：权晟 introduction The term “primary cutaneous lymphoma” refers to cutaneous T-cell lymphomas (CTCLs) and cutaneous B-cell lymphomas (CBCLs) that present in the skin with no evidence of extracutaneous disease at the time of diagnosis. Primary cutaneous lymphomas often have a completely different clinical behavior and prognosis from histologically similar systemic lymphomas, which may involve the skin secondarily, and therefore require different types of treatment.
Primary cutaneous lymphomas are currently classified by the European Organization for Research and Treatment of Cancer (EORTC) classification or the World Health Organization (WHO) classification, but both systems have shortcomings. During recent consensus meetings representatives of both systems reached agreement on a new classification, which is now called the WHO-EORTC classification. 蕈样霉菌病(MF)
蕈样霉菌病是一种常见嗜表皮性的皮肤T细胞淋巴瘤（CTCL），特点是增生的小至中等大小的T淋巴细胞，有“脑回样”的核。MF是最常见的皮肤T细胞淋巴瘤，约占所有皮肤原发性淋巴瘤的50%。
临床特征：
MF多发在成人，有惰性的临床病程、进展缓慢，从斑块到浸润的斑块最后到肿瘤经时数年，有时可达十几年。在部分病人，淋巴结和内脏器官可能会在疾病的晚期被累及。肿块期的MF病人可特征性地同时出现斑点、斑块和瘤块，后者多出现溃疡。 组织病理学：MF的早期斑块状的病损表现为表浅的“条带样”或“苔藓样”浸润，主要成份是淋巴细胞和组织细胞。异型的瘤细胞数量不多，细胞小至中等大小、有“脑回状”的核，多数局限在表皮（嗜表皮性）。肿瘤细胞特征性地沿表皮的基底层生长，呈“晕环状”或“线状”的排列。出现表皮间的异型淋巴细胞的聚集（Pautrier微脓肿）是一种特征性的特点，但仅可见于一小部分病例。
免疫表型：MF中的肿瘤细胞有成熟型的CD3+、CD4+、CD45RO+、CD8－的T记忆细胞的免疫表型。出现奇异的表型（如丢失全T细胞抗原CD2、CD3、CD5等）常见，可作为诊断MF的参考指标。
遗传学特征：克隆性的T细胞受体基因重排见于多数病例。许多染色体的结构和数目的异常已有描述，尤其是进展期的MF，但恒定的MF特异的染色体异位还未发现。10号染色体长臂的缺失和P15、P16、P53肿瘤抑制基因的异常可见于多数的MF患者。
预后及预测因素：MF患者的预后取决于分期。局限性的斑片/斑块期的MF患者，10年生存率是97~98%；弥漫的斑片/斑块期的MF患者是83%；肿块期的是42%。
Sézary syndrome (SS)
Sézary综合症包括了既往的“红皮病”、泛发的淋巴结病和在皮肤、淋巴结及血液中出现肿瘤性T细胞（Sézary细胞）的三联症。
临床特征：SS是一种罕见病，毫无例外地发生在成人。特征性地表现为红皮病，可相关性地出现明显褪皮、水肿和“苔藓样”硬化，这会造成奇痒。淋巴结病、秃头、甲床萎缩和掌柘部位角化亢进是常见的症状。
组织病理学：SS最主要的特征与MF的特征类似。然而SS中的浸润细胞成分更单一，可无“嗜表皮现象”。累及淋巴结时可特征性地出现出弥漫、单一的Sézary细胞浸润，伴有淋巴结正常结构的破坏。 免疫表型：肿瘤性的T细胞呈CD3+、CD4+、CD8－的表型。血循环中的Sézary细胞常表现出CD7和CD26的
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