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你可能喜欢第二科研楼313guohw@
郭红卫教授，教育部“长江学者奖励计划”特聘教授、国家杰出青年基金获得者、深圳市国家级领军人才、深圳市孔雀计划海外高层次人才B；长期从事植物分子生物学及遗传学方面研究，在植物激素生物学领域具有很深的造诣。揭示了植物激素乙烯信号转导的一系列的分子及生化机制，在国际上率先建立了乙烯作用的蛋白降解模型和RNA降解模型；揭示了乙烯与多种植物激素（生长素、茉莉素、赤霉素）以及与环境信号（光、胁迫）之间的相互作用机理；在Cell、Science、Nature、PNAS、Plant Cell等国际刊物发表论文54篇，授权发明专利4项；2005年全职回国后，任北京大学生命科学学院教授、博士生导师，筹建了植物激素信号转导实验室。2016年起，任南科大生物系讲席教授，受南方科技大学委托筹建植物与食品研究所并担任首届研究所所长，承担《植物生理学》、《分子生物学》本科生课程和《科学实践训练》研究生课程的教学工作。现任中国植物学会青年工作委员会主任，中国植物生理和植物分子生物学学会植物成熟衰老专业委员会副主任，中国作物学会常务理事等学术组织重要职务及Mol Plant、PCP、 JIPB、JGG等学术刊物编委会成员。
◆ 植物激素信号转导
◆ 植物衰老与采后生物学
◆ 植物siRNA生物学
2016 – 至今
南方科技大学生物系 讲座教授
北京大学生命科学学院 教授
美国加州Salk Institute
美国加州大学洛杉矶分校(UCLA)
植物分子生物学专业
北京大学生命科学学院 生物技术专业
南开大学生物系 植物生理专业
获奖情况及荣誉
◆2016 深圳市孔雀计划海外高层次人才B
◆2016 深圳市国家级高层次人才领军人才
◆2015 科技部中青年科技创新领军人才
◆2014 谈家桢生命科学创新奖
◆2013 中国科协“科学中国人（2012）年度人物
◆2011 第十二届“中国青年科技奖”
◆2009 第十三届“中国青年五四奖章”称号
◆2008 中国植物学会先进青年科技工作者称号
◆2007 第二十二届北京市“五四奖章”标兵称号
◆2006 国家自然科学基金委“杰出青年科学基金”
◆2006 教育部“长江学者奖励计划”特聘教授
1. Wen Song,*, Li Liu,*, Jizong Wang, Zhen Wu, Heqiao Zhang, Jiao Tang, Guangzhong Lin1, Yichuan Wang, Xing Wen, Wenyang Li, Zhifu Han, Hongwei Guo* and Jijie Chai*(2016). Signature motif-guided identification of receptors for peptide hormones essential for root meristem growth. Cell Research, 26:674–685
2. Song W., Liu L., Wang J., Wu Z., Zhang H., Tang J., Lin G., Wang Y., Wen X., Li W., Han Z., Guo H.*, Chai J.* (2016). Signature motif-guided identification of receptors for peptide hormones essential for root meristem growth. Cell Research. 26:674-85.
3. Li M., An F., Li W., Ma M., Feng Y., Zhang X., Guo H.* (2016). DELLA proteins interact with FLC to repress flowering transition. J Integr Plant Biol. 58:642-55.
4. Zhang X., Zhu Y., Wu H., Guo H.* (2016). Post-transcriptional gene silencing in plants: a double-edged sword. Sci China Life Sci. 59:271-6.
5. Zhu Z., Xian Z., Guo H.* Li Z.* (2016). Ethylene Biology Blooms from Fundamental Research to Postharvest Applications. Mol Plant. 9:187-8.
6. Qing D., Yang Z., Li M., Wong WS., Guo G., Liu S., Guo H., Li N. (2016). Quantitative and Functional Phosphoproteomic Analysis Reveals that Ethylene-Regulates Water Transport via the C-terminal Phosphorylation of Aquaporin PIP2;1 in Arabidopsis. Mol Plant. 9:158-74.
1. Li W., Ma M., Feng Y., Li H., Wang Y., Ma Y., Li M., An F., and Guo H.* (2015). EIN2-directed translational regulation of ethylene signaling in Arabidopsis. Cell, 163: 670-683.
2.Zhang X., Zhu Y., Liu X., Hong X., Xu Y., Zhu P., Shen Y., Wu H., Ji Y., Wen X., Zhang C., Zhao Q., Wang Y., Lu J. and Guo H.* (2015). Suppression of endogenous gene silencing by bidirectional cytoplasmic RNA decay in Arabidopsis. Science, 348: 120-123.
3. Song J., Zhu C., Zhang X., Wen X., Liu L., Peng J., Guo H.*, Yi C.* (2015). Biochemical and Structural Insights into the Mechanism of DNA Recognition by Arabidopsis ETHYLENE INSENSITIVE3. PLoS One.10:e0137439.
1. Peng J., Li Z., Wen X., Li W., Shi H., Yang L., Zhu H. and Guo H.* (2014). Salt-Induced Stabilization of EIN3/EIL1 Confers Salinity Tolerance by Diminishing ROS Accumulation in Arabidopsis. PLoS Genetics, 10:e1004664
2. Zhang X., Zhu Z., An F., Hao D., Li P., Song J., Yin C., and Guo H.* (2014) Jasmonate-Activated MYC2 Represses ETHYLENE INSENSITIVE3 activity to antagonize ethylene-promoted apical hook formation in Arabidopsis. Plant Cell 26:1105-17.
3. Zhong S., Shi H., Xue C., Wei N., Guo H.* and Deng X.* (2014) An ethylene-orchestrated circuitry coordinates a seedling’s response to soil cover and etiolated growth. Proc. Natl. Acad. Sci. U S A, 111:3913-20. ( *Co-Corresponding)
1.Li Z., Peng J., Wen X. and Guo H.* (2013).
ETHYLENE-INSENSITIVE3 is a senescence-associated
accelerates
age-dependent
senescence
by directly repressing miR164 transcription in Arabidopsis. Plant Cell 25:3311-28
2.Zhang X, Chen Y, Lin X, Hong X, Zhu Y, Li W, He W, An F, Guo H.* (2013) Adenine Phosphoribosyl Transferase 1 is a key enzyme catalyzing cytokinin conversion from nucleobases to nucleotides in Arabidopsis. Mol Plant. 6:1661-72
3.Song S, Qi T, Fan M, Zhang X, Gao H, Huang H, Wu D, Guo H, Xie D. (2013) The bHLH Subgroup IIId Factors Negatively Regulate Jasmonate-Mediated Plant Defense and Development. PLoS Genet. J9(7):e1003653.
4.Ji Y and Guo H.* (2013). From endoplasmic reticulum (ER) to nucleus: EIN2 bridges the gap in ethylene signaling. Mol Plant. 6:11-4.
5.Zheng D, Han X, An Y, Guo H, Xia X, Yin W. (2013). The nitrate transporter NRT2.1 functions in the ethylene response to nitrate deficiency in Arabidopsis. Plant Cell Environ. Jan 11. doi: 10.1111/pce.12062.
6.Li H, Xu T, Lin D, Wen M, Xie M, Duclercq J, Bielach A, Kim J, Reddy GV, Zuo J, Benková E, Friml J, Guo H, Yang Z.(2013). Cytokinin signaling regulates pavement cell morphogenesis in Arabidopsis. Cell Res. 23:290-9.
7.Kim H., Kwon S., Jang Y., Nam M., Chung J., Na Y., Guo H. and Park O. (2013). GDSL LIPASE1 modulates plant immunity through feedback regulation of ethylene signaling. Plant Phys. 163:1776-91.
2012: 1.Wen X, Zhang C, Ji Y, Zhao Q, He W, An F, Jiang L, Guo H.* (2012). Activation of ethylene signaling is mediated by nuclear translocation of the cleaved EIN2 carboxyl terminus. Cell Res. 22:1613-6.
2.Wang Q, Fristedt R, Yu X, Chen Z, Liu H, Lee Y, Guo H, Merchant SS, Lin C. (2012). The γ-carbonic anhydrase subcomplex of mitochondrial complex I is essential for development and important for photomorphogenesis of Arabidopsis. Plant Physiology 160:1373-83.
3.Zhong S., Shi H., Xue C., Wang L., Xi Y., Li J., Quail P.H., Deng X.*, and Guo H.* (2012). A Molecular Framework of Light-Controlled Phytohormone Action in Arabidopsis. Current Biology 22: 1530-35
4.Men Y., Yu Q., Chen Z., Wang J., Huang Y.* and Guo H.* (2012). A high-throughput imaging system to quantitatively analyze the growth dynamics of plant seedlings. Integrative Biology 4:945-52.
5.Shi Y., Tian S., Hou L., Huang X., Zhang X., Guo H. and Yang S. (2012). Ethylene signaling negatively regulates freezing tolerance by repressing expression of CBF and Type-A ARR genes in Arabidopsis. Plant Cell 24:2578-95.
6.Li Z, Peng J, Wen X, Guo H.* (2012). Gene Network Analysis and Functional Studies of Senescence-associated Genes Reveal Novel Regulators of Arabidopsis Leaf Senescence. J Integr Plant Biol. 54:526-39.
7.An F., Zhu Z., Zhang X., Ji Y., He W., Jiang Z., Li M., and Guo H.* (2012). Coordinated regulation of apical hook development by gibberellin and ethylene in etiolated Arabidopsis seedlings. Cell Res. 22: 915-27.
2011: 1.He W., Brumos J., Li H., Ji Y., Ke M., Gong X., Zeng Q., Li W., Zhang X., An F., Wen X., Li P., Chu J., Sun X., Yan C., Yan N., Xie D., Raikhel N., Yang Z., Stepanova A.N., Alonso J.M. and Guo H.* (2011). A small-molecule screen identifies L-Kynurenine as a competitive inhibitor of TAA1/TAR activity in ethylene-directed auxin biosynthesis and root growth in Arabidopsis. Plant Cell 23:3944-60
2.Stepanova A.N., Yun J., Robles L.M., Novak O., He W., Guo H., Ljung K., Alonso J.M. (2011). The Arabidopsis YUCCA1 flavin monooxygenase functions in the Indole-3-Pyruvic Acid branch of auxin biosynthesis. Plant Cell 23:3961-73
3.Zhu Z., An F., Feng Y., Li P., Xue L., A M., Jiang Z., Kim J., To T., Li W., Yu Q., Dong Z., Chen W., Seki M., Zhou J. and Guo H.* (2011). Derepression of ethylene-stabilized transcription factors (EIN3/EIL1) mediates jasmonate and ethylene signaling synergy in Arabidopsis . Proc. Natl. Acad. Sci. USA. 108:12539-44.
4.Zhao Q. and Guo H.* (2011). Paradigms and paradox in the ethylene signaling pathway and interaction network. Mol. Plant 4:626-34
5.Li H., Lin D., Dhonukshe P., Nagawa S., Chen D., Friml J., Scheres B., Guo H., Yang Z. (2011). Phosphorylation switch modulates the interdigitated pattern of PIN1 localization and cell expansion in Arabidopsis leaf epidermis. Cell Res. 21:970-8
6.Jiang Z, Liu X, Peng Z, Wan Y, Ji Y, He W, Wan W, Luo J,* Guo H.* (2011). AHD2.0: an update version of Arabidopsis Hormone Database for plant systematic studies. Nucleic Acids Research 39: D1123-9. ( *Co-Corresponding Author)
7.Liu X., Li Z. Jiang Z., ZhaoY., Peng J., Jin J., Guo H*., Luo J.* (2011). LSD: a leaf senescence database. Nucleic Acids Research 39: D1103-7. ( *Co-Corresponding Author)
An F., Zhao Q., Ji Y., Jiang Z., Yu X., Liu Y., Han Y., Zhang C., Zhang S., Ecker J.R., and Guo H.* (2010). Ethylene-Induced Stabilization of ETHYLENE INSENSITIVE3 and EIN3-LIKE1 Is Mediated by Proteasomal Degradation of EIN3 Binding F-Box 1 and 2 That Requires EIN2 in Arabidopsis . Plant Cell 22:
2.Jiang Z. and Guo H.* (2010). A comparative genomic analysis of plant hormone related genes in different species. J. Genet. Genomics 37:219-30
3.Zhong S., Shi H., Xi Y. and Guo H.* (2010). Ethylene is crucial for cotyledon greening and seedling survival during de-etiolation. Plant Signaling & Behavior 5: 739-42
2009: 1.Zhong S., Zhao M., Shi T., Shi H., An F., Zhao Q. and Guo H.* (2009). EIN3/EIL1 cooperate with PIF1 to prevent photo-oxidation and to promote greening of Arabidopsis seedlings. Proc. Natl. Acad. Sci. USA. 106: 21431-36.
2.Peng Z., Zhou X., Li L., Yu X., Li H., Jiang Z., Cao G., Bai M., Wang X., Jiang C., Lu H., Hou X., Qu L.,Wang Z., Zuo J., Fu X., Su Z., Li S., and Guo H.* (2009). Arabidopsis Hormone Database: a comprehensive genetic and phenotypic information database for plant hormone research in Arabidopsis. Nucleic Acids Research 37: 975-82.
3.Chen H., Xue L., Chintamanani S., Germain H., Lin H., Cui H., Cai R., Zuo J., Tang X., Li X., Guo H., and Zhou J. (2009). ETHYLENE INSENSITIVE3 and ETHYLENE INSENSITIVE3-LIKE1 repress SALICYLIC ACID INDUCTION DEFICIENT2 expression to negatively regulate plant innate immunity in Arabidopsis. Plant Cell 21:2527-40.
4.Li H., Wong W., Zhu L., Guo H., Ecker J.R., and Li N. (2009). Phosphoproteomic analysis of ethylene-regulated protein phosphorylation in etiolated seedlings of Arabidopsis mutant ein2 using two-dimensional separations coupled with a hybrid quadruple time-of-flight mass spectrometer. Proteomics 9:1646-61.
2008: 1. Zhu Z. and Guo H.* (2008). Genetic basis of ethylene perception and signal transduction in Arabidopsis. Journal of Integrative Plant Biology 50: 808-15.
2007: 1. Li H. and Guo H.* (2007). Molecular basis of the ethylene signaling and response pathway in Arabidopsis. Journal of Plant Growth Regulation 26: 106-17.
2006: 1.Olmedo G., Guo H., Gregory B., Nourizadeh S., Aguilar-Henonin L., Li H., An F., Guzman P., and Ecker J.R. (2006). ETHYLENE-INSENSITIVE5 encodes a 5’→3′ exoribonuclease required for posttranscriptional regulation of the EIN3-targeting F-box proteins EBF1/2. Proc. Natl. Acad. Sci. USA. 103: 13286-93 (* co-first author).
2.An F., and Guo H.* (2006) The Molecular Mechanism of Ethylene Signal Transduction.Chinese Botany Bulletin 23: 531-42.
Before 2005:
1.Guo H. and Ecker J.R. (2004). The ethylene signaling pathway: new insights. Curr Opin Plant Biol. 7: 40-9.
2.Guo H. and Ecker J.R. (2003). Plant responses to ethylene gas are mediated by SCFEBF1/EBF2-dependent proteolysis of EIN3 transcription factor. Cell 115: 667-77.
3.Shalitin D., Yang H., Mockler T., Maymon M., Guo H., Whitelam G., and Lin C. (2002). Regulation of Arabidopsis cryptochrome 2 by blue light-dependent phosphorylation. Nature 417: 763-7.
4.Guo H., Mockler T., Duong H., and Lin C. (2001). SUB1, an Arabidopsis Ca2+-binding protein involved in cryptochrome and phytochrome coaction. Science 291: 487-90.
5.Guo H., Duong H., Ma N., and Lin C. (1999). The Arabidopsis blue light receptor cryptochrome 2 is a nuclear protein regulated by a blue light-dependent post-transcriptional mechanism. Plant J. 19: 279-87.
6.Mockler T., Guo H., Yang H., Duong H., and Lin C. (1999). Antagonistic actions of the Arabidopsis cryptochromes and phytochrome B in the regulation of floral induction. Development 126: 2073-82.
7.Guo H., Yang H., Mockler T., and Lin C. (1998). Regulation of flowering time by Arabidopsis photoreceptors. Science 279: 1360-3.
(1998). Enhancement of blue-light sensitivity of Arabidopsis seedling by a blue light receptor cryptochrome 2. Proc. Natl. Acad. Sci. USA 95: 2686-90.
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10 July 2017
Amid increasingly extreme projections for future sea-level rise, concerns are mounting that policymakers are struggling to keep abreast of fast-paced scientific developments. To ease this burden and increase the accessibility of published research, we have compiled an editor-curated collection of the most recent sea-level rise articles published at Nature Communications.
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28 July 2017
Genes and circuits involved in sleep and sexual arousal have been extensively studied in Drosophila. Here the authors identify the sex determination genes fruitless and doublesex, and a sex-specific P1-DN1 neuronal feedback that governs the interaction between these competing behaviors
Dandan Chen, Divya Sitaraman, Nan Chen, Xin Jin, Caihong Han, Jie Chen, Mengshi Sun, Bruce S. Baker, Michael N. Nitabach&&&Yufeng Pan
Corrigendum
28 July 2017
Thomas Moreau, Amanda L. Evans, Louella Vasquez, Marloes R. Tijssen, Ying Yan, Matthew W. Trotter, Daniel Howard, Maria Colzani, Meera Arumugam, Wing Han Wu, Amanda Dalby, Riina Lampela, Guenaelle Bouet, Catherine M. Hobbs, Dean C. Pask, Holly Payne, Tatyana Ponomaryov, Alexander Brill, Nicole Soranzo, Willem H. Ouwehand, Roger A. Pedersen&&&Cedric Ghevaert
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ATM and TP53 mutations are associated with poor prognosis in chronic lymphocytic leukaemia (CLL). Here the authors generate mouse models of Tp53- and Atm-defective CLL mimicking the high-risk form of human disease and show that Atm-deficient CLL is sensitive to PARP1 inhibition.
Gero Knittel, Tim Rehk?mper, Darya Korovkina, Paul Liedgens, Christian Fritz, Alessandro Torgovnick, Yussor Al-Baldawi, Mona Al-Maarri, Yupeng Cun, Oleg Fedorchenko, Arina Riabinska, Filippo Beleggia, Phuong-Hien Nguyen, F. Thomas Wunderlich, Monika Ortmann, Manuel Montesinos-Rongen, Eugen Tausch, Stephan Stilgenbauer, Lukas P. Frenzel, Marco Herling, Carmen Herling, Jasmin Bahlo, Michael Hallek, Martin Peifer, Reinhard Buettner, Thorsten Persigehl&&&H. Christian Reinhardt
28 July 2017
Proper brain function depends on the correct assembly of excitatory and inhibitory neurons into neural circuits. Here the authors show that during early postnatal development in mice, NMDAR signaling via activity of long-range synaptic inputs onto neurogliaform cells is required for their appropriate integration into the hippocampal circuitry.
R. Chittajallu, J. C. Wester, M. T. Craig, E. Barksdale, X. Q. Yuan, G. Akgül, C. Fang, D. Collins, S. Hunt, K. A. Pelkey&&&C. J. McBain
28 July 2017
Human chromosomes are captured along microtubule walls and then tethered to microtubule-ends through a multi-step end-on conversion process. Here the authors show that Aurora-B regulates end-on conversion in human cells and establish a late role for Astrin-SKAP complex in the end-on conversion process.
Roshan L. Shrestha, Duccio Conti, Naoka Tamura, Dominique Braun, Revathy A. Ramalingam, Konstanty Cieslinski, Jonas Ries&&&Viji M. Draviam
28 July 2017
Reliable estimates of the total forest carbon (C) pool are lacking due to insufficient information on dead organic matter (DOM). Here, the authors estimate that the current DOM C stock in China is 925 ± 54 Tg and that it grew by 6.7 ± 2.2 Tg C/yr over the past two decades primarily due to increasing forest area
Jianxiao Zhu, Huifeng Hu, Shengli Tao, Xiulian Chi, Peng Li, Lai Jiang, Chengjun Ji, Jiangling Zhu, Zhiyao Tang, Yude Pan, Richard A. Birdsey, Xinhua He&&&Jingyun Fang
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Lund University, Centre for Environmental and Climate Reserarch
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