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地 & & & &址：广东省广州市广州大学城外环东路132号中山大学药学院
·教育和科研工作经历
年：香港理工大学应用生物及化学科技学系&&&&&&&&&&&&&&&&&&&&& & &博士学位
年：中国科学院成都有机化学研究所&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&硕士学位
年：四川大学化学系 & & & & & & & & & & & & & & & & & & & & & & & & & & & & & &学士学位
科研工作经历
2016.08-至今：中山大学药学院教授；中山大学药学院院长；
：华东师范大学化学系教授；上海市高校“东方学者” 特聘教授（2009-）；华东师范大学小分子药物研究所所长（）；上海分子治疗与新药创制工程技术研究中心主任（）；
年：美国施贵宝制药公司，高级研究员（制药工艺），美国新泽西；
年：美国GeneSoft制药公司，研究员（药物化学），美国旧金山；
年：美国亚利桑那大学化学系博士后；
年：中国科学院成都有机化学研究所先后任实习研究员（1990），助理研究员（1993），副研究员（1997）。不对称合成联合开放实验室副主任（1992），课题组长（1992），其间公派到香港理工大学攻读博士学位。
·学术任职
上海市药物化学专门委员会委员
化学学报编委
化学快报编委
中国化学会手性化学专业委员会委员
·荣誉与获奖情况
2016年国务院特殊津贴专家；
2015年国家百千万人才工程人选，有突出贡献中青年专家；
2014年 教育部“长江学者” 特聘教授；
2011年 国家杰出青年基金获得者；
2010年 教育部自然科学二等奖；
2010年 Asian Core Program Lectureship Award；
2009年 上海市高校“东方学者”特聘教授；
2009年 “上海市优秀学科带头人”；
2008年 Thieme Chemistry Journal Award；&
2007年 上海市“浦江计划”；
2006年 上海市“曙光学者”；&
2005年 “四川省学术和技术带头人”；
2002年 四川省科学技术进步一等奖；&
2000年 中国科学院“百人计划”入选者；&
1994年 四川省科学技术进步二等奖。
·发表论文
发表研究论文152篇&
代表性论文
1. Dan Zhang, Jun Zhou, Fei Xia, Zhenghui Kang, and Wenhao Hu*, Bond cleavage, fragment modification and reassembly in enantioselective three-component reactions, Nat Commun. 2015, 6, 5801.
2. Xiaochu Ma, Jun Jiang, Siying Lv, Wenfeng Yao, Yang Yang, Shunying Liu,* Fei Xia, and Wenhao Hu*, An Ylide Transformation of Rhodium(I) Carbene: Enantioselective Three-Component Reaction through Trapping of Rhodium(I)-Associated Ammonium Ylides by β-Nitroacrylates, Angew. Chem. Int. Ed. 2014, 53, .
3. Dan Zhang, Huang Qiu, Liqin Jiang,* Fengping Lv, Chaoqun Ma, and Wenhao Hu*,. Enantioselective Palladium(II) Phosphate Catalyzed Three-Component Reactions of Pyrrole, Diazoesters, and Imines. Angew. Chem. Int. Ed. 2013, 125, .
4. Shikun Jia, Dong Xing, Dan Zhang, and Wenhao Hu*, Catalytic Asymmetric Functionalization of Aromatic C-H Bonds by Electrophilic Trapping of Metal-Carbene-Induced Zwitterionic Intermediates, Angew. Chem. Int. Ed. 2014, 53, .
5. Changcheng Jing, Dong Xing, Yu Qian, Taoda Shi, Yun Zhao, and Wenhao Hu*, Diversity-Oriented Three-Component Reactions of Diazo Compounds with Anilines and 4-Oxo-Enoates. Angew. Chem. Int. Ed. 2013, 52, .
6. Xin Guo, and Wenhao Hu*, Novel Multicomponent Reactions via Trapping of Protic Onium Ylides with Electrophiles, Acc. Chem. Res. 2013, 46, .
7. Jun Jiang, Xiaoyu Guan, Shunying Liu, Baiyan Ren, Xiaochu Ma, Xin Guo, Fengping Lv, Xiang Wu, and Wenhao Hu*, Highly Diastereoselective Multicomponent Cascade Reactions: Efficient Synthesis of Functionalized 1-Indanols, Angew. Chem. Int. Ed. 2013, 52, .
8. Huang Qiu, Ming Li, Li-Qin Jiang, Feng-Ping Lv, Li Zan, Chang-Wei Zhai, Michael P. Doyle, and Wen-Hao Hu*, Highly enantioselective trapping of zwitterionic intermediates by imines, Nature Chem. 2012, 4, 733-739.
9. Jun Jiang, Hua-Dong Xu, Jian-Bei Xi, Bai-Yan Ren, Feng-Ping Lv, Xin Guo, Li-Qin Jiang, Zhi-Yong Zhang, and Wenhao Hu*, Diastereoselectively Switchable Enantioselective Trapping of Carbamate Ammonium Ylides with Imines, J. Am. Chem. Soc. 2011, 133, .
10. Xiaoyu Guan, Liping Yang, and Wenhao Hu*, Cooperative Catalysis in Multicomponent Reactions: Highly Enantioselective Synthesis of γ-Hydroxyketones with a Quaternary Carbon Stereocenter, Angew. Chem. Int. Ed. 2010, 49, .
11. Xu Zhang, Haoxi Huang, Xin Guo, Xiaoyu Guan, Liping Yang, and Wenhao Hu*, Catalytic enantioselective trapping of an alcoholic oxonium ylide with aldehydes: Rh-II/Zr-IV-co-catalyzed three-component reactions of aryl diazoacetates, benzyl alcohol, and aldehydes, Angew. Chem. Int. Ed. 2008, 47, .
12. Wenhao Hu*, Xinfang Xu, Jing Zhou, Wei-Jun Liu, Haoxi Huang, Juan Hu, Liping Yang, and Liu-Zhu Gong*, Cooperative Catalysis with Chiral Br?nsted Acid-Rh2(OAc)4: Highly Enantioselective Three-Component Reactions of Diazo Compounds with Alcohols and Imines, J. Am. Chem. Soc. 2008, 130, .
13. Haoxi Huang, Xin Guo, and Wenhao Hu*, Efficient Trapping of Oxonium Ylides with Imines: A Highly Diastereoselective Three-Component Reaction for the Synthesis of β-Amino-α-hydroxyesters with Quaternary Stereocenters, Angew. Chem. Int. Ed. 2007, 46, .
14. Xufeng Cao, Zhaoshuan Sun, Yongbing Cao, Ruilian Wang, Tongkai Cai, Wenjing Chu, Wenhao Hu*, and Yushe Yang*, Design, Synthesis, and Structure-Activity Relationship Studies of Novel Fused Heterocycles-Linked Triazoles with Good Activity and Water Solubility, J. Med. Chem. 2014, 57, .
15. Brendan Frett, Robert V. Brown, Mingliang Ma, Wenhao Hu, Haiyong Han, and Hong-yu Li*, Therapeutic Melting Pot of Never in Mitosis Gene A Related Kinase2 (Nek2): A Perspective on Nek2 as an Oncology Target and Recent Advancements in Nek2 Small Molecule Inhibition, J. Med. Chem. 2014, 57, .
16. Shouning Yang, Wei Shi, Dong Xing, Zheng Zhao,** Fengping Lv, Liping Yang, Yushe Yang,** and Wenhao Hu*, Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria, Eur. J. Med. Chem. 2014, 86, 133-152.
17. Wei Shi, Haikun Ma, Yuejiao Duan, Kelly Aubart, Yuhong Fang, Rimma Zonis, Liping Yang, Wenhao Hu*, Design, synthesis and antibacterial activity of 3-methylenepyrrolidine formyl hydroxyamino derivatives as novel peptide deformylase inhibitors, Bioorg. Med. Chem. Lett. 2011, 21, .
18. Wei Shi, Yuejiao Duan, Yu Qian, Ming Li, Liping Yang, and Wenhao Hu*, Design, synthesis, and antibacterial activity of 2,5-dihydropyrrole formyl hydroxyamino derivatives as novel peptide deformylase inhibitors, Bioorg. Med. Chem. Lett. 2010, 20, .
其他论文（详见附件页）
·参与撰写的专著
1. 《Multicomponent Reactions in Organic Synthesis》
2. 《实用有机合成工艺研发手册》
3. 《有机化学学科前沿与展望》
4. 《高速发展的中国化学》
5. 《不对称催化反应进展》
·发表专利
&申请国内外发明专利103余项，其中有32项专利已获授权。
代表性授权专利
1. 胡文浩，江俊，管晓渝，郭鑫，马晓初，刘顺英；一种多取代茚醇衍生物的制备方法；专利号：ZL.1。
2. 胡文浩，昝力，厉铭，黄海峰，周静，张霞，杨琍苹；一种3，3'-二取代-3-羟基双吲哚酮衍生物及其制备方法和应用；专利号：ZL.0。
3. 胡文浩，石炜，段月娇，钱宇，厉铭，杨琍苹；含2,5-二氢吡咯的肽脱甲酰基酶抑制剂及合成方法；专利号：ZL.9。正在申请国际专利,PCT/CN，已授权。
4. 胡文浩，徐新芳，郭新，邱林，周静，杨琍苹；一种合成多芳基取代噁唑烷的方法；专利号：ZL.0。
5. 胡文浩，史滔达，郭震球，杨琍苹；一种制备α-羟基-β-氨基丙酸乙酯衍生物的方法；专利号：ZL .X。
6. 胡文浩，朱映光，翟昌伟，岳永力，杨琍苹；一种二氢吡咯衍生物的制备方法；专利号：ZL.X。
代表性申请专利
1. 胡文浩，翟昌伟，马超群，荆常诚，邢栋；一种螺[吡咯啉基-3,2’-氧化吲哚]衍生物及其合成方法和应用；申请号：.3。
2. 胡文浩，马明亮，席间备，吕思莹，王文科，章雄文，方艳芬；一种咪唑并吡啶骨架结构的新化合物的合成及应用；申请号：.2。
3. 胡文浩，周俊，张丹，邢栋，刘顺英； 硫酸化岩藻-半乳四糖及其制备方法和应用；申请号：.4。
附件页:论文清单
1. Jian-Bei Xi, Ming-Liang Ma, and Wenhao Hu*, Rh2(OAc)4 and InCl3 co-catalyzed diastereoselective trapping of carbamate ammonium ylides with aldehydes for the synthesis of β-hydroxyl-α-amino acid derivatives, Tetrahedron 2016, 72, 579-583.
2. Mingfeng Li, Xin Guo, Weifeng Jin,Qing Zheng, Shunying Liu,* and Wenhao Hu*, Enantioselective Three-component Reaction of Diazoacetates with Indoles and Enals by Iridium/Iminium Co-catalysis, Chem. Commun. 2016, 52, .
3. Jiuwei Che, Dong Xing,* and Wenhao Hu*, Metal-Catalyzed Cross-Coupling of Terminal Alkynes with Different Carbene Precursors, Current Organic Chemistry, 2016, 20, 41-60.
4. Min Tang, Yong Wu, Yuan Liu, Maoqiang Cai, Fei Xia, Shunying Liu,* and Wenhao Hu*, One-pot Enantioselective Multi-component Cascade Reactions for Synthesis of Chiral Functionalized Hydro-epoxyisochromenes: A Rapid Access to Molecular Complexity, Acta Chim. Sinica 2016, 74, DOI: 10.27.
5. Changcheng Jing, Dong Xing,* Lixin Gao, Jia Li, and Wenhao Hu*, Divergent Synthesis of Multisubstituted Tetrahydrofurans and Pyrrolidines via Intramolecular Aldol-type Trapping of Onium Ylide Intermediates, Chem. Eur. J. 2015, 21, .
6. Catalytic Asymmetric Four-Component Reaction for the Rapid Construction of 3,3'-Disubstituted 3-Indol-3'-yloxindoles, Changcheng Jing, Dong Xing,* and Wenhao Hu*, Org. Lett. 2015, 17, .
7. Taoda Shi, Xin Guo, Shenghan Teng, and Wenhao Hu*, Pd(II)-catalyzed formal [4+1] cycloaddition reactions of diazoacetates and aryl propargyl alcohols to form 2,5-dihydrofurans, Chem Commun. 2015, 51, .
8. Dan Zhang, Jun Zhou, Fei Xia, Zhenghui Kang, and Wenhao Hu*, Bond cleavage, fragment modification and reassembly in enantioselective three-component reactions, Nat Commun. 2015, 6, 5801.
9. Fengping Lv , Zhi-fang Li, Wenhao Hu*, and Xiaohua Wu*, Small molecules enhance functional O-mannosylation of α-dystroglycan, Bioorg. Med. Chem. 2015, 23, .
10. Divergent Synthesis of Chiral Heterocycles via Sequencing of Enantioselective Three-Component Reactions and One-Pot Subsequent Cyclizations, Min Tang, Dong Xing,* Haoxi Huang, and Wenhao Hu*, Chem Commun. 2015, 51, .
11. Changcheng Jing, Dong Xing,* Chengjin Wang, and Wenhao Hu*, Synthesis of 3-(hydroxymethyl)-3-indol-3'-yloxindoles via Rh(II)-catalyzed three-component reaction of 3-diazooxindoles, indoles and formalin, Tetrahedron 2015, 71, .
12. Min Tang, Dong Xing, Maoqiang Cai, and Wenhao Hu*, Diazo Compounds-Involved Catalytic Asymmetric Multicomponent Reactions, Chin. J. Org. Chem. 2014, 34, .
13. Changwei Zhai, Dong Xing, Yu Qian, Jingjing Ji, Chaoqun Ma, and Wenhao Hu*, Trapping of Carboxylic Oxonium Ylides with N-Boc Imines for the Facile Synthesis of β-Amino Alcohol Derivatives, Synlett 2014, 25, .
14. Changcheng J Dong Xing, Yu Qian, and Wenhao Hu*, Rh2(OAc)4 and Chiral Phosphoric Acid Cocatalyzed Highly Diastereo- and Enantioselective Four-Component Reactions: Facile Synthesis of Chiral α,β-Diamino Acid Derivatives, Synthesis-Stuttgart 2014, 46, .
15. Xufeng Cao, Zhaoshuan Sun, Yongbing Cao, Ruilian Wang, Tongkai Cai, Wenjing Chu, Wenhao Hu*, and Yushe Yang*, Design, Synthesis, and Structure-Activity Relationship Studies of Novel Fused Heterocycles-Linked Triazoles with Good Activity and Water Solubility, J. Med. Chem. 2014, 57, .
16. Changwei Zhai, Dong Xing*, Changcheng Jing, Jun Zhou, Chengjin Wang, Dongwei Wang, and Wenhao Hu*, Facile Synthesis of 3-Aryloxindoles via Br?nsted Acid Catalyzed Friedel-Crafts Alkylation of Electron-Rich Arenes with 3-Diazooxindoles, Org. Lett. 2014, 16, .
17. Hua-Dong Xu,* Mao-Qiang Cai, Wei-Jie He, Wen-Hao Hu and Mei-Hua Shen*, Interception of benzyne with thioethers: a facile access to sulfur ylides under mild conditions, RSC Adv. 2014, 4, .
18. Dong Xing, and Wenhao Hu*, Recent advances in metal carbenoid mediated nitrogen-containing zwitterionic intermediate trapping process, Tetrahedron Lett. 2014, 55, 777-783.
19. Shikun Jia, Dong Xing, Dan Zhang, and Wenhao Hu*, Catalytic Asymmetric Functionalization of Aromatic C-H Bonds by Electrophilic Trapping of Metal-Carbene-Induced Zwitterionic Intermediates, Angew. Chem. Int. Ed. 2014, 53, .
20. Jun Zhou, Liping Yang, and Wenhao Hu*, Stereoselective Synthesis of a Sulfated Tetrasaccharide Corresponding to a Rare Sequence in the Galactofucan Isolated from Sargassum polycystum, J. Org. Chem. 2014, 79, .
21. Shouning Yang, Wei Shi, Dong Xing, Zheng Zhao,** Fengping Lv, Liping Yang, Yushe Yang,** and Wenhao Hu*, Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria, Eur. J. Med. Chem. 2014, 86, 133-152.
22. Chengjin Wang, Dong Xing,* Dongwei Wang, Xiang Wu, and Wenhao Hu*,Synthesis of 3-Amino-3-hydroxymethyloxindoles and 3-Hydroxy-3-hydroxymethyloxindoles by Rh2(OAc)4-Catalyzed Three-Component Reactions of Diazooxindoles with Formaldehyde and Anilines or Water, J. Org. Chem. 2014, 79, .
23. Brendan Frett, Robert V. Brown, Mingliang Ma, Wenhao Hu, Haiyong Han, and Hong-yu Li*, Therapeutic Melting Pot of Never in Mitosis Gene A Related Kinase2 (Nek2): A Perspective on Nek2 as an Oncology Target and Recent Advancements in Nek2 Small Molecule Inhibition, J. Med. Chem. 2014, 57, .
24. Lin Qiu, Lixin Gao, Jixing Tang, Dongwei Wang, Xin Guo, Shunying Liu *, Liping Yang, Jia Li, Wenhao Hu*, Regio- and Diastereoselective Construction of α-Hydroxyl-δ-Amino Esters Derivatives via 1,4-Conjugate Addition of β,γ-Unsaturated N-Sulfonyl Imines, J. Org. Chem., 2014, 79, .
25. Xin Guo, Wei Liu, and Wenhao Hu*, A Facile Access to Polyfunctional Oxygen-containing Heterocycles via Intramolecularly Formed Protic Oxonium Ylide Trapping Processes, Chem. Asian J. 2014, 9, 117-120.
26. Changcheng Jing, Dong Xing, and Wenhao Hu*, Highly diastereoselective synthesis of 3-hydroxy-2,2,3-trisubstituted indolines via intramolecular trapping of ammonium ylides with ketones, Chem. Commun. 2014, 50, 951-953.
27. Jun Jiang, Xiaochu Ma, Changge Ji, Zhengqiu Guo, Taodao Shi, Shunying Liu*, and Wenhao Hu*, Ruthenium(II)/Chiral Br?nsted Acid Co-Catalyzed Enantioselective Four-Component Reaction/Cascade Aza-Michael Addition for Efficient Construction of 1,3,4-Tetrasubstituted Tetrahydroisoquinolines, Eur. Chem. J. 2014, 20, .
28. Yi Ni, Xin Guo, Wenhao Hu, and Shunying Liu*, Asymmetric N-H Insertion Reaction of α-Diazoesters and Carbamates through Co-catalyzed by Dirhodium Acetate, Sufonic Acid and Chiral Sul-fonamide Urea, Chin. J. Org. Chem. 2014, 34, 107-111.
29. Xiaochu Ma, Jun Jiang, Siying Lv, Wenfeng Yao, Yang Yang, Shunying Liu,* Fei Xia, and Wenhao Hu*, An Ylide Transformation of Rhodium(I) Carbene: Enantioselective Three-Component Reaction through Trapping of Rhodium(I)-Associated Ammonium Ylides by β-Nitroacrylates, Angew. Chem. Int. Ed. 2014, 53, .
30. Lin Qiu, Xin Guo, Chaoqun Ma, Huang Qiu, Shunying Liu,* Liping Yang and Wenhao Hu*. Efficient synthesis of chiral cyclic acetals by metal and Br?nsted acid co-catalyzed enantioselective four-component cascade reactions, Chem. Commun. 2014, 50, .
31. Lin Qiu, Dongwei Wang, Fengping Lv, Xin Guo, Wenhao Hu, Liping Yang, and Shunyin Liu*, Three-component reactions based on trapping ammonium ylides with N-sulfonyl aldimines via cooperative catalysis of squaramides and Rh2(OAc)4, Tetrahedron 2014, 70, .
32. Xin Guo, Wei Liu, and Wenhao Hu*, A Facile Access to Polyfunctional Oxygen-containing Heterocycles via Intramolecularly Formed Protic Oxonium Ylide Trapping Processes, Chem. Asian J. 2014, 9, 117-120.
33. Dan Zhang, Huang Qiu, Liqin Jiang,* Fengping Lv, Chaoqun Ma, and Wenhao Hu*,. Enantioselective Palladium(II) Phosphate Catalyzed Three-Component Reactions of Pyrrole, Diazoesters, and Imines. Angew. Chem. Int. Ed. 2013, 125, .
34. Chaoqun Ma, Dong Xing,* Changwei Zhai, Jiuwei Che, Shunying Liu, Jue Wang, and Wenhao Hu*, Iron Porphyrin-Catalyzed Three-Component Reaction of Ethyl Diazoacetate with Aliphatic Amines and β,γ-Unsaturated α-Keto Esters, Org. Lett. 2013, 15, .
35. Chengjin Wang, Shunying Liu*; Dong Xing, Xin Wang, Xiang Wu, and Wenhao Hu*, Efficient synthesis of α-aryl serine derivatives via three-component reactions of aryldiazoacetates, anilines and formaldehyde, Tetrahedron 2013, 69, . Lin Qiu, Xin Guo, Jun Zhou, Shunying Liu*; Liping Yang, Xiang Wu, and Wenhao Hu*, A stereoselective synthesis of fully substituted tetrahydrofurans through 1,3-dipolar cycloaddition with cinnamaldehydes: an easy access to chroman derivatives, RSC Adv. 2013, 3, .
36. Liqin Jiang, Dan Zhang, Zhongqing Wang, and Wenhao Hu*, Highly Enantioselective Three-Component Reactions of tert-Butyl Diazoacetate with Arylamines and Imines: An Efficient Synthesis of α,β-Bis(arylamino) Acid Derivatives, Synthesis-Stuttgart, 2013, 45, 452-458.
37. Fengping Lv, Shunying Liu, and Wenhao Hu*, Recent Advances in the Use of Chiral Br?nsted Acids as Cooperative Catalysts in Cascade and Multicomponent Reactions, Asian J. Org. Chem. 2013, 2, 824-836.
38. Yu Qian, Peter Y. Zavalij, Wenhao Hu*, and M. P. Doyle*, Bicyclic Pyrazolidinone Derivatives from Diastereoselective Catalytic [3+3]-Cycloaddition Reactions of Enoldiazoacetates with Azomethine Imines, Org. Lett. 2013, 15, .&
39. Hua-Dong Xu,* Ren-Wei Zhang, Xiaoxun Li, Suyu Huang, Weiping Tang, and Wen-Hao Hu*, Rhodium-Catalyzed Chemo- and Regioselective Cross-Dimerization of Two Terminal Alkynes, Org. Lett. 2013, 15, 840-843.
40. Xinfang Xu, Peter Y. Zavalij, Wenhao Hu, and Michael P. Doyle*, Vinylogous Reactivity of Enol Diazoacetates with Donor-Acceptor Substituted Hydrazones. Synthesis of Substituted Pyrazole Derivatives, J. Org. Chem. 2013, 78, .
41. Manas M. Sarmah, Dipak Prajapati,* and Wenhao Hu, Synthesis of Novel and Complex Tetrahydroquinazolinedione and Dihydropyrido[2,3-d]pyrimidine Derivatives via a One-Pot [4+2]-Cycloadddition Strategy, Synlett 2013, 4, 471-474.
42. Manas M. Sarmah, Rupam Sarma, Dipak Prajapati,* and Wenhao Hu, Efficient synthesis of dihydropyrido[4,3-d]pyrimidines by microwave-promoted three-component aza-Diels-Alder reaction. Tetrahedron Lett. 2013, 54, 267-271.
43. Xin Guo, and Wenhao Hu*, Novel Multicomponent Reactions via Trapping of Protic Onium Ylides with Electrophiles, Acc. Chem. Soc. 2013, 46, .
44. Changcheng Jing, Dong Xing, Yu Qian, Taoda Shi, Yun Zhao, and Wenhao Hu*, Diversity-Oriented Three-Component Reactions of Diazo Compounds with Anilines and 4-Oxo-Enoates. Angew. Chem. Int. Ed. 2013, 52, .
45. Dong Xing,* Changcheng Jing, Xinfeng Li, Huang Qiu, and Wenhao Hu*, Highly Efficient Synthesis of Mixed 3,3-Bisindoles via Rh(II)-Catalyzed Three-Component Reaction of 3-Diazooxindoles with Indoles and Ethyl Glyoxylate, Org. Lett. 2013, 15, .
46. Changcheng Jing, Taoda Shi, Dong Xing, Xin Guo, and Wen-Hao Hu*, CuSO4 catalyzed three-component reaction of α-diazo ester, water and isatin: an efficient and green approach to oxindole derivatives. Green Chem. 2013, 15, 620-624.
47. Jun Jiang, Xiaochu Ma, Shunying Liu, Yu Qian, Fengping Lv, Lin Qiu, and Wenhao Hu*, Enantioselective Trapping of Phosphoramidate Ammonium Ylides with Imino Esters for Synthesis of 2,3-Diaminosuccinic Acid Derivatives, Chem. Commun. 2013, 49, .
48. Yu Qian, Changcheng Jing, Shunying Liu, and Wenhao Hu*, A Highly Enantioselective Four-Component Reaction for the Efficient Construction of Chiral ss-Hydroxy-α-Amino Acid Derivatives, Chem. Commun. 2013, 49, .
49. Jun Jiang, Xiaoyu Guan, Shunying Liu, Baiyan Ren, Xiaochu Ma, Xin Guo, Fengping Lv, Xiang Wu, and Wenhao Hu*, Highly Diastereoselective Multicomponent Cascade Reactions: Efficient Synthesis of Functionalized 1-Indanols, Angew. Chem. Int. Ed. 2013, 52, .
50. Huang Qiu, Dan Zhang, Shun-ying Liu, Lin Qiu, Jun Zhou, Yu Qian, Chang-wei Zhai, Wen-hao Hu*, Asymmetric C-H functionalization of indoles via enantioselective protonation, Acta Chim. Sinica 2012, 70, . &
51. Huang Qiu, Ming Li, Li-Qin Jiang, Feng-Ping Lv, Li Zan, Chang-Wei Zhai, Michael P. Doyle, and Wen-Hao Hu*, Highly enantioselective trapping of zwitterionic intermediates by imines, Nature Chem. 2012, 4, 733-739.
52. Yu Qian, Xinfang Xu, Xiaochen Wang, Peter J. Zavalij, Wenhao Hu, and Michael P. Doyle*, Rhodium(II)- and Copper(II)-Catalyzed Reactions of Enol Diazoacetates with Nitrones: Metal Carbene versus Lewis Acid Directed Pathways, Angew. Chem. Int. Ed. 2012, 51, .
53. Yu Qian, Changcheng Jing, Changwei Zhai, and Wen-hao Hu*, A Novel Method for Synthesizing N-Alkoxycarbonyl Aryl α-Imino Esters and Their Applications in Enantioselective Transformations, Adv. Synth. Catal. 2012, 354, 301-307.
54. Xinfang Xu, Peter Y. Zavalij, Wenhao Hu, and Michael P. Doyle*, Efficient synthesis of oxazoles by dirhodium(II)-catalyzed reactions of styryl diazoacetate with oximes, Chem. Commun. 2012, 48, .
55. Jingjing Ji, Xia Zhang, Liqing Jiang, and Wenhao Hu*, InBr catalyzed three-component reactions of an aryldiazoacetate, an alcohol, and a carbonyl compound, Tetrahedron Lett. 2012,53,182-185.
56. Xia Zhang, Jingjing Ji, Yingguang Zhu, Changcheng Jing, Ming Li, and Wenhao Hu*, Highly diastereoselective three-component tandem 1,4-conjugated addition/cyclization reaction to multisubstituted pyrrol, Org. Biomol.Chem. 2012, 10, .
57. Ming Li, Li Zan, Dipak Prajapatib, and Wenhao Hu*, Rhodium(II) catalyzed diastereoselective reactions of diazoacetamides with isatins: an efficient approach to 3-hydroxy-3,3′-bioxindoles, Org. Biomol. Chem. 2012, 10, .
58. Xiao-na Chen, Wen-hao Hu, Xiao-Liu Li and Hua-dong Xu, Synthesis of β-Diazo-α-ketoamides and their cyclopropanation reaction with alkenes, Chin. J. Syn Chem. 2012, 20, 19-22.&
59. Ying-Guang Zhu, Hong-Zhu Kan, Li-Qin Jiang, and Wen-Hao Hu*, Practical and Scalable Synthesis of Ethyl (R)-Piperidine-3-acetate, Syn. Commun. 2012, 42, .
60. Yu Qian, Xinfang Xu, Xiaochen Wang, Peter J. Zavalij, Wenhao Hu, and Michael P. Doyle*, Rhodium(II)- and Copper(II)-Catalyzed Reactions of Enol Diazoacetates with Nitrones: Metal Carbene versus Lewis Acid Directed Pathways, Angew. Chem. Int. Ed. 2012, 51, .
61. Xinfang Xu, Wen-Hao Hu, and Michael P. Doyle*, Highly Enantioselective Catalytic Synthesis of Functionalized ChiralDiazoacetoacetates, Angew. Chem. Int. Ed. 2011, 50, .
62. Jun Jiang, Hua-Dong Xu, Jian-Bei Xi, Bai-Yan Ren, Feng-Ping Lv, Xin Guo, Li-Qin Jiang, Zhi-Yong Zhang, and Wenhao Hu*, Diastereoselectively Switchable Enantioselective Trapping of Carbamate Ammonium Ylides with Imines, J. Am. Chem. Soc. 2011, 133, .
63. Xinfang Xu, Wen-Hao Hu*, Peter Y. Zavalij, and Michael P. Doyle*, Divergent Outcomes of Carbene Transfer Reactions from Dirhodiumand Copper-Based Catalysts Separately or in Combination, Angew. Chem. Int. Ed. 2011, 50, .
64. Yu Qian, Changcheng Jing, Taoda Shi, Jingjing Ji, Min Tang, Jing Zhou, Changwei Zhai, and Wenhao Hu*, Dual Catalysiisn Highly Enantioselectiv Multicomponent Reactionw with Water:A n Efficient Approach to Chiral β-Amino-α-Hydroxy acid Derivative, ChemCatChem 2011, 3, 653-656.
65. Jingjing Ji, Xia Zhang, Yingguang Zhu, Yu Qian, Jing Zhou, Liping Yang, and Wenhao Hu*, Diastereoselectivity Switch in Cooperatively Catalyzed Three-Component Reactions of an Aryldiazoacetate, an Alcohol, and a β,γ-Unsaturated α-Keto Ester, J. Org. Chem. 2011, 76, .
66. Wei Shi, Haikun Ma, Yuejiao Duan, Kelly Aubart, Yuhong Fang, Rimma Zonis, Liping Yang, Wenhao Hu*, Design, synthesis and antibacterial activity of 3-methylenepyrrolidine formyl hydroxyamino derivatives as novel peptide deformylase inhibitors, Bioorg. Med. Chem. Lett. 2011, 21, .
67. Xingchun Han, Liqing Jiang, Min Tang, and Wenhao Hu*, Diastereoselective three-component reactions of aryldiazoacetates with alcohols/water and alkynals: application to substituted enelactones, Org. Biomol. Chem. 2011, 9, .
68. Xingchun Han, Minghua Gan, Huang Qiu, Jingjing Ji, Xia Zhang, Liqing Jiang, and Wenhao Hu*, Trapping of Oxonium Ylides with Michael Acceptors: Highly Diastereoselective Three-Component Reactions of Diazo Compounds with Alcohols and Benzylidene Meldrum's Acid/4-Oxo-enoate, Synlett 2011, .
69. Wenhao Hu*, Jing Zhou, Xinfang Xu, Weijun Liu, and Liuzhu Gong*, (R)-33'-Bis(9-phenanthryl)-1,1'-binaphthalene-2,2'-diylhydrogen Phosphate, Org. Synth. 2011, 88, 406-417.
70. Jing Zhou, Xinfang Xu, and Wenhao Hu*, Enantioselective three-component reaction for the preparation of β-amino-α-hydroxy esters, Org. Synth. 2011, 88, 418-426.
71. Qinyao Xu, Jianghui Yu and Wenhao Hu*, Liping Yang, A New Route for the Preparation of Orlistat, Chinese Journal of Organic Chemistry, 2010, 30, .
72. Yu Qian, Xinfang Xu, Liqin Jiang, Dipak Prajapati, and Wenhao Hu*, A Strategy to Synthesize Taxol Side Chain and (-)-epi Cytoxazone via Chiral Br?nsted Acid-Rh2(OAc)4 Co-catalyzed Enantioselective Three-Component Reactions, J. Org. Chem. 2010, 75, .
73. Yingguang Zhu, Changwei Zhai, and Wenhao Hu*, Asymmetric Multicomponent Reactions, Progress in Chemistry, 2010, 22, .
74. Xiaoyu Guan, Liping Yang, and Wenhao Hu*, Cooperative Catalysis in Multicomponent Reactions: Highly Enantioselective Synthesis of γ-Hydroxyketones with a Quaternary Carbon Stereocenter, Angew. Chem. Int. Ed. 2010, 49, .
75. Yingguang Zhu, Changwei Zhai, Liping Yang, and Wenhao Hu*, Copper(II)-catalyzed highly diastereoselective three-component reactions of aryl diazoacetates with alcohols and chalcones: an easy access to furan derivatives, Chem. Commun. 2010, 46, .
76. Wei Shi, Yuejiao Duan, Yu Qian, Ming Li, Liping Yang, and Wenhao Hu*, Design, synthesis, and antibacterial activity of 2,5-dihydropyrrole formyl hydroxyamino derivatives as novel peptide deformylase inhibitors, Bioorg. Med. Chem. Lett. 2010, 20, .
77. Zhenqiu Guo, Mei Cai, Jun Jiang, Liping Yang, and Wenhao Hu*, Rh2(OAc)4-AgOTf Cooperative Catalysis in Cyclization/Three-Component Reactions for Concise Synthesis of 1,2-Dihydroisoquinolines, Org. Lett. 2010, 12, 652-655.
78. Xin Guo, Jingjing Wang, Liping Yang, and Wenhao Hu*, Rh(II) Catalyzed Three-Component Reactions of Diazoacetates with Benzenemethanol and Indane-1,2,3-Triones, Lett. Org. Chem. 2010, 7, 106-109.
79. Zhenqiu Guo, Taoda Shi, Jun Jiang, Liping Yang, and Wenhao Hu*, Component match in rhodium catalyzed three-component reactions of ethyl diazoacetate, H2O and aryl imines: a highly diastereoselective one-step synthesis of β-aryl isoserine derivatives, Org. Biomol. Chem. 2009, 7, .
80. Xinfang Xu, Xingchun Han, Liping Yang,* and Wenhao Hu*, Highly Diastereoselective Synthesis of Fully Substituted Tetrahydrofurans by a One-Pot Cascade Reaction of Aryldiazoacetates with Allyl Alcohols, Chem-Eur. J. 2009, 15, .
81. Xiao-Yu Guan, Zhang-Qin Liu, Hao-Xi Huang, Li-Ping Yang, Liao Jian,* and Wen-Hao Hu*, Novel C-S Bond Formation Through α’,β-Elimination of tert-Butyl Sulfoxonium Ylides: A Facile Approach to Chiral Sulfoxides, Synlett. 2009, 13, .
82. Dongyin Dong, Liping Yang, and Wenhao Hu*, Organic Reactions with Carbon Dioxide, Prog. Chem. 2009, 6, .
83. Xu Zhang, Xin Guo, Liping Yang, and Wenhao Hu*, Rh(II) and Zn(II) co-catalyzed multi-component reaction for the synthesis of vicinal diols, Chinese Chem. Lett. 2009, 20, .
84. Xu Zhang, Na Zhang, Xin Guo, Liping Yang, and Wenhao Hu*, Rhodium(II) catalyzed multi-component reactions of aryldiazoacetates with titanium(IV) isopropoxide and imines, Tetrahedron 2009, 39, .
85. Xin Guo, Yongli Yue, Guoliang Hu, Jing Zhou, Yiqing Zhao, Liping Yang, and Wenhao Hu*, Trapping of an Ammonium Ylide with Activated Ketones: Synthesis of β-Hydroxy-α-Amino Esters with Adjacent Quaternary Stereocenters, Synlett 2009, 13, .
86. Xu Zhang, Haoxi Huang, Xin Guo, Xiaoyu Guan, Liping Yang, and Wenhao Hu*, Catalytic enantioselective trapping of an alcoholic oxonium ylide with aldehydes: Rh-II/Zr-IV-co-catalyzed three-component reactions of aryl diazoacetates, benzyl alcohol, and aldehydes, Angew. Chem. Int. Ed. 2008, 47, .
87. Wenhao Hu*, Xinfang Xu, Jing Zhou, Wei-Jun Liu, Haoxi Huang, Juan Hu, Liping Yang, and Liu-Zhu Gong*, Cooperative Catalysis with Chiral Br?nsted Acid-Rh2(OAc)4: Highly Enantioselective Three-Component Reactions of Diazo Compounds with Alcohols and Imines, J. Am. Chem. Soc. 2008, 130, .
88. Yongli Yue, Xin Guo, Zhiyong Chen, Liping Yang, and Wenhao Hu*, Copper(?) hexafluorophosphate: a dual functional catalyst for three-component reactions of methyl phenyldiazoacetate with alcohols and aldehydes or α-ketoesters, Tetrahedron Letters. 2008, 49, .
89. Xinfang Xu, Jing Zhou, Liping Yang, and Wenhao Hu*, Selectivity control in enantioselective four-component reactions of aryl diazoacetates with alcohols, aldehydes and amines: an efficient approach to synthesizing chiral β-amino-α-hydroxyesters, Chem. Commun. 2008, 44, .
90. Haoxi Huang, and Wenhao Hu*, An efficient route for the construction of cyclopenta[b]quinoline derivatives via intramolecular cyclopropanation, Tetrahedron 2007, 63, .
91. Haoxi Huang, Xin Guo, and Wenhao Hu*, Efficient Trapping of Oxonium Ylides with Imines: A Highly Diastereoselective Three-Component Reaction for the Synthesis of β-Amino-α-hydroxyesters with Quaternary Stereocenters, Angew. Chem. Int. Ed. 2007, 46, .
92. Yongli Yue, Huayuan Wang, and Wenhao Hu*, Regioselectivity in Lewis acids catalyzed X-H (O, S, N) insertions of methyl styryldiazoacetate with benzyl alcohol, benzyl thiol, and aniline, Tetrahedron Lett. 2007, 48, .
93. Haoxi Huang, and Wenhao Hu*, Rhodium-catalyzed reaction of diazoacetates, thiols and azodicarboxylates: An unusual 1,2-aza shift from a sulfonium ylide, Synlett 2007, 8, .
94. Xin Guo, Haoxi Huang, Liping Yang, and Wenhao Hu*, Trapping of Oxonium Ylide with Isatins:
Efficient and Stereoselective Construction of Adjacent Quaternary Carbon Centers, Org. Lett. 2007, 9, .
95. Zhenqiu Guo, Haoxi Huang, Hingyuan Hu, and Wenhao Hu*, Facile synthesis of aryl α-keto esters via the reaction of aryl diazoacetate with H2O and DEAD, Synlett 86-2488.
96. Haoxi Huang, Yuanhua Wang, Zhiyong Chen, and Wen-Hao Hu*, A Novel Synthesis of Aryl α-Imino Esters from Aryl Diazoacetate., Synlett 2005, 16, .
97. Wei-Jun Liu, Zhen-Liang Chen, Zhi-Yong Chen, and Wen-Hao Hu*, Dirhodium catalyzed intramolecular enantioselective C–H insertion reaction of N-cumyl-N-(2-p-anisylethyl) diazoacetamide: synthesis of (-)-Rolipram. Tetrahedron: Asymmetry 2005, 16, .
98. Zhi-Cheng Li, Zhi-Yong Chen, Wen-Hao Hu*, and Xiao-Qi Yu*, Rh(II) Catalyzed Aziridination of Diazobenzylphosphonate with Arylimines, Acta Chimica Sinica 2005, 12, .
99. Zhi-Cheng Li, Ji Zhang, and Wen-Hao Hu*, Zhi-Yong Chen, and Xiao-Qi Yu*, Rhodium Acetate-Mediated Epoxidation from the Reaction of Diazobenzyl-phosphonates with Aldehydes and a Ketone: A Convenient and Highly Stereoselective Synthetic Method of cis-1,2-Epoxypropylphosphonates, Synlett 2005, 11, .
100. Haoxi Huang, Yuanhua Wang, Zhiyong Chen, and Wenhao Hu*, Rhodium-Catalyzed, Three-Component Reaction of Diazo Compounds with Amines and Azodicarboxylates, Adv. Synth. Catal. 2005, 347, 531-534.
101. Chong-Dao Lu, Hui Liu, Zhi-Yong Chen, Wen-Hao Hu*, and Ai-Qiao Mi*, The rhodium catalyzed three-component reaction of diazoacetates, titanium(IV) alkoxides and aldehydes. Chem. Commun. 2005, .
102. Zhenliang Chen, Zhiyong Chen, Yaozhong Jiang, and Wenhao Hu*, The synthesis of baclofen and GABOB via Rh(II) catalyzed intramolecular C–H insertion of α-diazoacetamides. Tetrahedron, 2005, 61, .
103. Chong-Dao Lu, Hui Liu, Zhi-Yong Chen, Wen-Hao Hu*, and Ai-Qiao Mi. Three-Component Reaction of Aryl Diazoacetates, Alcohols, and Aldehydes (or Imines):
Evidence of Alcoholic Oxonium Ylide Intermediates, Org. Lett. 2005, 7, 83-86.
104. Yan-Xin Zhu, Yuan-Hua Wang, Zhi-Yong Chen, and Wen-Hao Hu*, Unexpected Side Reaction in the Intermolecular N-H Insertion of Phenyl Diazoacetates with Arylamines. Chinese Chem. Lett. 2005, 16, 307-310.
105. Chong-Dao Lu, Zhi-Yong Chen, Hui Liu, Wen-Hao Hu*, and Ai-Qiao Mi, A Facile Three-Component One-Pot Synthesis of Structurally Constrained Tetrahydrofurans That Are t-RNA Synthetase Inhibitor Analogues, J. Org. Chem. 2004, 69, .
106. Zhenliang Chen, Zhiyong Chen, Yaozhong Jiang, and Wenhao Hu*, Cumyl: A Better N-Protecting Group of α-Diazo Acetamides for Intra-molecular C-H Insertion Reaction and its Application in the Synthesis of Pregabalin and 3-Benzyloxy Pyrrolidine, Synlett 2004, 10, .
107. Zhenjun Du, Zhenliang Chen, Zhiyong Chen, Xiaoqi Yu, and Wenhao Hu*, Dirhodium-catalyzed enantioselective C–H insertion of N-(2-benzyloxyethyl)-N-(tert-butyl)diazoacetamide and its application for the synthesis of chiral GABOB, Chirality 2004, 16, 516-519.
108. Roland W. Bürli, Dustin McMinn, Jacob A. Kaizerman, Wenhao Hu, Yigong Ge, Quinn Pack, Vernon Jiang, Matthew Gross, Martin Garcia, Richard Tanaka, and Heinz E. Moser*, DNA binding ligands targeting drug-resistant Gram-positive bacteria. Part 1: Internal benzimidazole derivatives, Bioorg. Med. Chem. Lett. 2004, 14, .
109. Wenhao Hu, Roland W. Bürli, Jacob A. Kaizerman, Kirk W. Johnson, Matthew I. Gross, Mari Iwamoto, Peter Jones, Denene Lofland, Stacey Difuntorum, Hsiu Chen, Bülent Bozdogan, Peter C. Appelbaum, and Heinz E. Moser*, DNA Binding Ligands with Improved in Vitro and in Vivo Potency against Drug-Resistant Staphylococcus aureus, J. Med. Chem. 2004, 47, .
110. Roland W. Burli, Jacob A. Kaizerman, Jian-Xin Duan, Peter Jones, Kirk W. Johnson, Mari Iwamoto, Kiet Truong, Wenhao Hu, Timothy Stanton, Alfred Chen, Sofia Touami, MatthewGross, Vernon Jiang, Yigong Ge, and Heinz E. Moser*, DNA binding ligands with in vivo efficacy in murine models of bacterial infection: optimization of internal aromatic amino acids. Bioorg. Med. Chem. Lett. 2004, 14, .
111. Chong-Dao Lu, Zhi-Yong Chen, Hui Liu, Wen-Hao Hu*, and Ai-Qiao Mi, Highly Chemoselective 2,4,5-Triaryl-1,3-dioxolane Formation from Intermolecular 1,3-Dipolar Addition of Carbonyl Ylide with Aryl Aldehydes. Org. Lett. 2004, 6, .
112. Marcela Valenzuela, Michael P. Doyle,* Christine Hedberg, Wenhao Hu, and Alexandra Holmstrom, Influence of the Diene in the Hetero-Diels-Alder Reaction Catalyzed by Dirhodium(II) Carboxamidates, Synlett 2004, 13, .
113. Yuanhua Wang, Zhiyong Chen, Aiqiao Mi, and Wenhao Hu*, Novel C–C bond formation through addition of ammonium ylides to arylaldehydes: a facile approach to β-aryl-β-hydroxy α-amino acid frameworks. Chem. Commun. 2004, .
114. Ming Yan, Neil Jacobsen, Wenhao Hu, Luisa S. Gronenberg, Michael P. Doyle,* John T. Colyer, and Darren Bykowski, Stereoselective Synthesis of Bicyclic Pyrrolidines by a Rhodium-Catalyzed Cascade Process, Angew. Chem. Int. Ed. 2004, 43, .
115. Zhenliang Chen, Zhiyong Chen, Yaozhong Jiang, and Wenhao Hu*, A Concise Synthesis of Gabapentin via Intramolecular C-H Insertion Reaction. Synlett 2003, 13, .
116. Yuanhua Wang, Yanxin Zhu, Zhiyong Chen, Aiqiao Mi, Wenhao Hu*, and Michael P. Doyle*, A Novel Three-Component Reaction Catalyzed by Dirhodium(II) Acetate:
Decomposition of Phenyldiazoacetate with Arylamine and Imine for Highly Diastereoselective Synthesis of 1,2-Diamines, Org. Lett. 2003, 5, .
117. Michael P. Doyle,* Wenhao Hu, and Thomas M. Weathers Jr. Comparative enantiocontrol with allyl phenyldiazoacetates in asymmetric catalytic intramolecular cyclopropanation, Chirality 2003, 15, 369-373.
118. Jacob A. Kaizerman, Matthew I. Gross, Yigong Ge, Sarah White, Wenhao Hu, Jian-Xin Duan, Eldon E. Baird, Kirk W. Johnson, Richard D. Tanaka, Heinz E. Moser, and Roland W. Bürli*, DNA Binding Ligands Targeting Drug-Resistant Bacteria:
Structure, Activity, and Pharmacology, J. Med. Chem. 2003, 46, .
119. Michael P. Doyle,* and Wenhao Hu, Enantioselectivity for catalytic cyclopropanation with diazomalonates, ARKIVOC 2003, 7, 15-22.
120. Michael P. Doyle,* Ming Yan, Wenhao Hu, and Luisa S. Gronenberg, Highly Selective Catalyst-Directed Pathways to Dihydropyrroles from Vinyldiazoacetates and Imines, J. Am. Chem. Soc. 2003, 125, .
121. Michael P. Doyle,* and Wenhao Hu, Enantioselective carbon--hydrogen insertion is an effective and efficient methodology for the synthesis of (R)-(-)-baclofen, Chirality 2002, 14, 169-172.
122. Wenhao Hu, Daren J. Timmons, and Michael P. Doyle*, In Search of High Stereocontrol for the Construction of cis-Disubstituted Cyclopropane Compounds. Total Synthesis of a Cyclopropane-Configured Urea-PETT Analogue That Is a HIV-1 Reverse Transcriptase Inhibitor. Org. Lett. 2002, 4, 901-904.
123. Michael P. Doyle,* Wenhao Hu, and Marcela V. Valenzuela, Total Synthesis of (S)-(+)-Imperanene, Effective Use of Regio- and Enantioselective Intramolecular Carbon-Hydrogen Insertion Reactions Catalyzed by Chiral Dirhodium(II) Carboxamidates. J. Org. Chem. 2002, 67, .
124. Michael P. Doyle,* Iain M. Phillips, and Wenhao Hu, A New Class of Chiral Lewis Acid Catalysts for Highly Enantioselective Hetero-Diels-Alder Reactions: Exceptionally High Turnover Numbers from Dirhodium(II) Carboxamidates, J. Am. Chem. Soc. 2001, 123, .
125. Michael P. Doyle,* and Wenhao Hu, A New Enantioselective Synthesis of Milnacipran and an Analogue by Catalytic Asymmetric Cyclopropanation, Adv. Synth. Catal. 2001, 343, 299-302.
126. Michael P. Doyle,* and Wen-Hao Hu, Enantiocontrol in Macrocycle Formation from Catalytic Metal Carbene Transformations, Chin. J. Chem. 2001, 19, 22-29.
127. Michael P. Doyle*, Wenhao Hu, and Daren J. Timmons, Epoxides and Aziridines from Diazoacetates via Ylide Intermediates, Org. Lett. 2001, 3, 933-935.
128. Michael P. Doyle,* Wenhao Hu, and Daren J. Timmons, Highly Stereoselective Syntheses of Five- and Seven-Membered Ring Heterocycles from Ylides Generated by Catalytic Reactions of Styryldiazoacetates with Aldehydes and Imines. Org. Lett. 2001, 3, .
129. Michael P. Doyle,* and Wenhao Hu, Macrocycle formation from catalytic metal carbene transformations, Synlett 2001, 9, .
130. Michael P. Doyl,* Wenhao Hu, Iain M. Phillips, Christopher J. Moody, Adrian G. Pepper, &and Alexandra M. Z. Slawinc, Reactivity Enhancement for Chiral Dirhodium(II) Tetrakis(Carboxamidates), Adv. Synth. Catal. 2001, 343, 112-117.
131. Michael P. Doyle,* Wenhao Hu, and Iain M. Phillips, A New Approach to Macrocyclization via Alkene Formation in Catalytic Diazo Decomposition: Synthesis of Patulolides A and B, Org. Lett. 2000, 2, .
132. Michael P. Doyle,* Simon B. Davies, and Wenhao Hu, Dirhodium(II) Tetrakis[methyl 2-oxaazetidine-4-carboxylate]:
A Chiral Dirhodium(II) Carboxamidate of Exceptional Reactivity and Selectivity, Org. Lett. 2000, 2, .
133. Michael P. Doyle,* Wenhao Hu, Brant Chapman, Alan B. Marnett, Chad S. Peterson, Justin P. Vitale, and Sarah A. Stanley, Enantiocontrolled Macrocycle Formation by Catalytic Intramolecular Cyclopropanation, J. Am. Chem. Soc. 2000, 122, .
134. Michael P. Doyle,* Simon B. Davies, and Wenhao Hu, Optimization of enantiocontrol in cis-selective cyclopropanation reactions catalyzed by dirhodium(II) tetrakis[alkyl 2-oxaazetidine-4(S)-carboxylates], Chem. Commun. 2000, 867-868.
135. Michael P. Doyle,* and Wenhao Hu, Reactivities and selectivities in macrocyclic addition reactions with diazoacetates using copper(I) and rhodium(II) catalysts, Tetrahedron Lett. 2000, 41, .
136. Michael P. Doyle,* and Wenhao Hu, Selectivity in Reactions of Allyl Diazoacetates as a Function of Catalyst and Ring Size from γ-Lactones to Macrocyclic Lactones, J. Org. Chem. 2000, 65, .
137. Wenhao Hu, Ming Yan, Chak-Po Lau, S. M. Yang, Albert S. C. Chan,* Yaozhong Jiang, and Aiqiao Mi, A Highly Effective Rhodium Spirocyclic Phosphinite Catalyst for the Asymmetric Hydrogenation of Enamides, Tetrahedron Lett. 2000, 41, 973-976.
138. Michael P. Doyl,* Brant J. Chapman, Wenhao Hu, Chad S. Peterson, M. Anthony McKervey, and Concepción F. Garcia, Catalytic Intramolecular Addition of Metal Carbenes to Remote Furans, Org. Lett. 1999, 1, .
139. Qing-hua Fan, Chang-yu Ren, Chi-hung Yeung, Wen-hao Hu, and Albert S. C. Chan*, Highly Effective Soluble Polymer-Supported Catalysts for Asymmetric Hydrogenation, J. Am. Chem. Soc. 1999, 121, .
140. Aiqiao Mi, Rongliang Lou, Yaozhong Jiang, Jingen Deng, Yong Qin, Fangmin Fu, Zhi Li, Wenhao Hu, and Albert S. C Chan*, Novel Chiral Aminophosphine Phosphinite Ligand and Its Application in Homogenous Catalytic Asymmetric Hydrogenation of Dehydroamino Acid Derivatives, Synlett. 1998, 8, 847-848.
141. Xiao-Ming Feng, Liu-Zhu Gong, Wen-Hao Hu, Zhi Li, Wei-Dong Pan, Ai-Qiao Mi, and Yao-Zhong Jiang, Chiral Schiff Base Ti(OR)4 Complexes Catalyzed Asymmetric Trimethylsilylcyanation of Aldehydes, Chem. J. Chinese U. 1998, 19, .
142. Wenhao Hu, Chih-Chiang Chen, Guoping Xue, and Albert S. C. Chan*, Synthesis of (-)-(4R,5R)-4,5-bis[di-3′-(2′,6′-dimethoxypyridyl)phosphinomethyl]-2,2-dimethyl-1,3-dioxolane and its application in the Rh-catalyzed asymmetric hydrogenation reactions, Tetrahedron-Asymmetry, 1998, 9, .
143. Yao-Zhong Jiang,* Minga Yan, Jian Sun, Wen-Hao Hu, Zhi Li, Ai-Qiao Mi, and Albert S. C. Chan, Chinese Journal of Chemistry 1998, 16, 258-263.
144. Albert S. C. Chan,* Wenhao Hu, Cheng-Chao Pai, and Chak-Po Lau, Yaozhong Jiang,* Aiqiao Mi, Ming Yan, Jian Sun, Rongliang Lou, and Jingen Deng, Novel Spiro Phosphinite Ligands and Their Application in Homogeneous Catalytic Hydrogenation Reactions, J. Am. Chem. Soc. 1997, 119, .
145. Yaozhong Jiang, Liuzhu Gong, Xiaoming Feng, Wenhao Hu, Weidong Pan, Zhi Li, and Aiqiao Mi, Salen-Ti(OR)4 complex catalysed trimethylsilylcyanation of aldehydes, Tetrahedron 1997, 53, .
146. Weidong Pan, Xiaoming Feng, Liuzhu Gong, Wenhao Hu, Zhi Li, Aiqiao Mi, and Yaozong Jiang, Chiral salen-titanium complexes-efficient catalysts for asymmetric trimethyl silylcyanation of benzaldehyde, Synlett. 1996, 6, 337-338.
147. Tay-Yuan Chau, Hsaio-Chi Lin, and Wenhao Hu, Complete Diastereofacial Selective Cycloaddition of New Sulfinyl Dienophiles (Ss)- and (Rs)-(-)Menthyl α-(2-Methoxyphenylsulfoxyl)acylate with Anthracene Under Chelation Control, Synthetic Commun. 1996, 26, .
148. Yaozhong Jiang, Xiangge Zhou, Wenhao Hu, Lanjun Wu, and Aiqiao Mi, Asymmetric catalytic trimethylsilylcyanation of benzaldehyde by novel Ti(IV)-chiral schiff base complexes, Tetrahedron-Asymmetry 1995, 6, 405-408
149. Albert S. C. Chan, Chi-Ching Lin, Jian Sun, Wenhao Hu, Zhi Li, Weidong Pan, Aiqiao Mi, Yaozhong JiangTsang-Miao Huang, Teng-Kuei Yang, Jyh-Horung Chen, Yu Wang, and &Gene-Hsiang Lee, Synthesis of spiro[4.4]nonane-1,6-diols via the hydrogenation of spiro[4.4]nonane-1,6-dione: the profound effect of hydrogenating agents, Tetrahedron-Asymmetry 1995, 6, .
150. Guilan Liu, Wenhao Hu, Yuzi Ma, Yaozhong Jiang, and Teng-Kuei Yang, Asymmetric Oxidative Coupling Reaction of Imine Carbanions via (+)-Camphor Chiral Template, Synthetic Commun. 1994, 24, .
151. Yaozhong Jiang, Wenhao Hu, Jingen Deng, and Liuzhu Gong, TiCl(Oipr)3-promoted asymetric coupling reaction of D-camphor ketamine anion, Synthetic Commun. 1991, 21, .
152. Yaozhong Jiang, Jingen Deng, Wenhao Hu, Liuzhu Gong, and Aiqiao Mi, stereoselective synthesis of α-alkyl-2-furfurylamines via D-camphor ketamine intermediate, Synthetic Commun. 1990, 20, .
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北京大学药学院
中国协和医科大学
沈阳药科大学
中国药科大学
德克萨斯大学奥斯汀分校药学院
普渡大学药学院
密歇根大学药学院
华盛顿大学药学院
犹他大学药学院