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硫酸头孢喹肟注射液
   本品为硫酸头孢喹肟与油酸乙酯等配制而成的混悬注射液。含头孢喹肟（C23H24N6O5S2）应为标示量的90.0%～105.0%。 【性状】 本品为类白色至浅褐色混悬液体；久置分层。 【鉴别】 （1）含量测定项下记录的色谱图中，供试品主峰的保留时间应与对照品峰的保留时间一致。 （2）取摇匀后的供试品2 ml，加水5 ml，稀盐酸1 ml，混匀，置超声浴中超声10分钟，弃去有机层，溶液显硫酸盐的鉴别反应（附录15页）。 【检查】有关物质  照含量测定项下的方法。 取摇匀后的供试品1.0 ml，加入流动相25.0 ml，置超声浴中超声5分钟，弃去有机层，取水层滤过，取续滤液10μl，注入液相色谱仪，记录色谱图，2,3-环己基吡啶与头孢喹肟相对保留时间为0.20。按峰面积归一化法计算，2,3-环己基吡啶应不得过3.0%，其他单一杂质应不得过0.50%，杂质总量应不得过4.0％。 水分  取本品，照水分测定法检查，含水分不得过0.2％。 细菌内毒素  取摇匀后的供试品2 ml与细菌内毒素检查用水3 ml混匀，分成2等份，振摇30秒，离心15分钟（2000g），吸取水层1 ml，加1 mol/L氢氧化钠溶液0.06 ml调节pH值至6.5～7.5。用细菌内毒素检查用水按1：10稀释后，照细菌内毒素检查法（附录73页）检查，每1 mg头孢喹肟中含细菌内毒素的量应小于0.1 EU。 无菌  取供试品8瓶，混合均匀，加入含6％吐温-80的蛋白胨缓冲液（1g/L）400ml，混匀，加入800×106单位青霉素酶（每1ml供试品溶液，加2×106单位青霉素酶），充分振摇，将供试品倒置，在37℃放置4小时；取供试品溶液，依法检查（附录79页，直接接种法），应符合规定。 分散性  取本品1瓶，振摇30秒，将供试品转移置玻璃容器中，不得观察到结块或沉淀物。 沉降  取本品1瓶，振摇30秒，取供试品10 ml置刻度试管中（内径1.0～1.5 cm），10分钟内不得沉淀。 粒度  取摇匀后的供试品，置显微镜下检查，颗粒直径在5μm以下应不得少于80％，10μm以下不得少于90％，20μm以下不得少于95％，50μm以下不得少于100％。 装量  按最低装量检查法检查，应符合规定。 【含量测定】 照高效液相色谱法测定。 色谱条件与系统适用性试验  用十八烷基硅烷键合硅胶为填充剂；取一水合高氯酸钠3.45g溶于1000 ml水中，加磷酸12 ml和乙腈90 ml，用三乙胺调节pH至3.6为流动相；检测波长为270 nm。取头孢噻肟约25 mg，溶于100.0 ml流动相中，另取头孢喹肟约25 mg，置25 ml量瓶中，精密加入上述头孢噻肟溶液1 ml，用流动相稀释至刻度。精密量取10μl注入液相色谱仪，记录色谱图；计算头孢喹肟与头孢噻肟的分离度，应大于1.0。 对照品溶液的制备  精密称取硫酸头孢喹肟对照品适量（约相当于头孢喹肟25 mg），置250 ml量瓶中，用流动相溶解并稀释至刻度，摇匀，即得。 供试品溶液的制备 精密量取摇匀后的供试品适量（约相当于头孢喹肟50 mg），精密加入流动相100 ml，置超声浴中超声5分钟，弃去油层，滤过；精密量取续滤液5 ml，置25 ml量瓶，加流动相稀释至刻度，摇匀，即得。 测定法  精密量取对照品溶液和供试品溶液各10μl，分别注入液相色谱仪，记录色谱图。按外标法以峰面积计算，即得。 【作用与用途】抗生素类药。主要用于治疗大肠杆菌引起的奶牛乳房炎，多杀性巴氏杆菌或胸膜肺炎放线杆菌引起的猪呼吸道疾病 【用法与用量】肌内注射  一次量  每1 kg体重 牛1 mg 一日1次  连用2日 猪2～3 mg 一日1次 连用3日 【休药期】牛 5日；猪 2日；弃奶期 1日。 【规格】 50ml:1.25g 【贮藏】遮光，25℃以下保存。 【有效期】 2年。 【生产企业】英特威国际有限公司（Intervet International GmbH） 注：蛋白胨缓冲液（1g/L） 蛋白胨（酪蛋白胨或肉蛋白胨）   1g KH2PO4                        3.6g Na2HPO4?2H2O                  7.2g NaCl                           4.3g 最终pH为7.0±0.2。溶液应无色澄清  
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硫酸头孢喹肟说明书
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长效头孢喹肟微球的研制及其在猪体内的药动学研究
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长效头孢喹肟微球的研制及其在猪体内的药动学研究
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头孢噻肟钠
头孢噻肟钠
头孢噻肟钠
Cefotaxime sodium salt
≥99.5%（HPLC)
C16H16N5NaO7S2
分子量477.45
Beilstein号
EC号 264-915-9
MDL号 MFCD
PubChem编号
上海 (10)天津 (5)
上海 (8)天津 (3)
上海 (>10)天津 (预计交期：3-5个工作日)
￥1,850.00
上海 (>10)天津 (预计交期：3-5个工作日)
￥6,998.00
￥2,799.20
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储存温度2-8°C
61 ° (C=1, H2O)
头孢噻肟钠 ;Cefotaxim sodium salt
Cg,Cg,Cmg,Cmg in glass bottle
警示性声明
个人防护设备
dust mask type N95 (US),Eyeshields,Faceshields,Gloves
危害码（欧洲）
风险声明 (欧洲)
安全声明（欧洲）
Merck Index
Phedias Diamandis, Jan Wildenhain, Ian D Clarke, Adrian G Sacher, Jeremy Graham, David S Bellows, Erick K M Ling, Ryan J Ward, Leanne G Jamieson, Mike Tyers, Peter B Dirks
We're sorry this abstract is currently not available....
Husein Husein El Ahmed, Guillermo Arturo Ca?adas-De la Fuente, Rafael Fernández-Castillo, Emilio González-Jiménez, Jesús Cantero-Hinojosa, Marita Lardón-Fernández
Cutaneous candidiasis is a disease that affects children as well as adults. The presentation may be localized or systemic, and with multiple etiological agents. The most prevalent infecting species in...
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Methicillin-resistant Staphylococcus aureus (MRSA) has emerged to be one of the most important pathogens both in health care and in community-onset infections. Daptomycin (DAP) is a cyclic anionic lip...
Muhammad Shahid Iqbal, Mohd Baidi Bahari, Yusrida Darwis, Muhammad Zahid Iqbal, Amer Hayat, Gantala Venkatesh
A simple and selective RP-HPLC-UV method with SPE was developed and validated for the quantification of cefotaxime in all-in-one total parenteral nutrition (AIO-TPN) admixtures. Chromatographic separa...
A Gerber, C Franz, J G Mainz
We're sorry this abstract is currently not available....
D Frasca, C Dahyot-Fizelier, W Couet, B Debaene, O Mimoz, S Marchand
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Dong Il Gwon, Sang Soo Lee, Eun-Young Kim
Background As bacterial attachment and subsequent biofilm formation on the surface of a stent lumen may be important in initiating sludge formation and subsequent stent blockage, there is a need for a...
I I Mounchetrou Njoya, Ae A Deghmane, Mk M Taha, H H Isnard, I I Parent du Chatelet
In April 2012, a cluster of two cases of meningococcal disease caused by rifampicin-resistant C meningococci was reported in the Champagne-Ardenne region, France. The two cases occurred in a student p...
Hisashi H Yoshida, Fumihiro F Kawai, Eiji E Obayashi, Satoko S Akashi, David I DI Roper, Jeremy R H JR Tame, Sam-Yong SY Park
Staphylococcus aureus is a widespread Gram-positive opportunistic pathogen, and a methicillin-resistant form (MRSA) is particularly difficult to treat clinically. We have solved two crystal structures...
Carlos C Hermoso Torregrosa, Manuel M Carrasco Zalvide, María Teresa MT Ferrer Castillo
We're sorry this abstract is currently not available....
Jitendra J Kumar, Sharad M SM Shukla, Vishnu V Bhat, Sanjay S Gupta, M G MG Gupta
Optimization of in vitro plant regeneration and genetic transformation of apomictic species such as Dichanthium annulatum would enable transfer of desirable genes. Seven genotypes of this grass specie...
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Rice (Oryza sativa ssp. indica) is an important economic crop in many countries. Although a variety of conventional methods have been developed to improve this plant, manipulation by genetic engineeri...
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'Leptotrichia amnionii' is an underestimated fastidious inhabitant of the vaginal flora that can cause upper genital tract infections when predisposing factors are present. We describe here ...
I M Baena, C Fernández, J Sánchez, M Calvente, V Aguadero
We're sorry this abstract is currently not available....
P-A Jarrot, R Mahmoudi, J-L Novella, P Manckoundia
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V Mozzetti, F Grattepanche, D Moine, B Berger, E Rezzonico, F Arigoni, C Lacroix
A central issue in the use of probiotics in food and food supplements is their sensitivity to many environmental stress factors. The resistance of probiotic cells to lethal stress can be improved by a...
Ruben Rocha, Lurdes Lisboa, Jo?o Neves, Milagros García López, Elsa Santos, Augusto Ribeiro
We report a case of a 5-year-old boy with acute disseminated encephalomyelitis as the initial presentation of neuroborreliosis. Parents report an upper-airway infection a few days before the developme...
Katrine Hartung Hansen, Peter Damborg, Margit Andreasen, S?ren Saxmose Nielsen, Luca Guardabassi
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Cláudia Cardoso, Isabelle Cremers, Ana Paula Oliveira
Spontaneous bacterial peritonitis (SBP) is a common and often serious complication of long standing ascites in the presence of advanced liver disease.1 We report a case of a 51- year-old man with alco...
Elena Ojer-Usoz, David González, Ana Isabel Vitas, José Leiva, Isabel García-Jalón, Alejandro Febles-Casquero, María de la Soledad Escolano
Patterns of resistance in β-lactamase-producing Enterobacteriaceae family were investigated in isolates from 141 meat products (beef, poultry and pork) purchased in Spain. The strains that grow in Ch...
Mohammad M MM Abd Elaal, Sahar G SG Zaghloul, Hoda Gouda HG Bakr, Mahmmoud Abdou MA Ashour, Hoda H Abdel-Aziz-El-Hady, Naglaa Ali NA Khalifa, Ghada E GE Amr
Spontaneous bacterial peritonitis (SBP) is a significant cause of mortality in cirrhosis. Reducing toxic burden of infected ascitic fluid through paracentesis needs further studies as adjunctive thera...
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Anil K AK Saxena, Bodh R BR Panhotra, Abdul Aziz AA Al-hafiz, Dasappan S DS Sundaram, Bassam B Abu-Oyun, Khalifa K Al Mulhim
Staphylococcus aureus nasal carriers undergoing hemodialysis (HD) through tunneled cuffed catheters (TCCs) form a high-risk group for the development of catheter-related bloodstream infections (CRBSI)...
Martijn F Schenk, Ivan G Szendro, Joachim Krug, J Arjan G M de Visser
For a quantitative understanding of the process of adaptation, we need to understand its "raw material," that is, the frequency and fitness effects of beneficial mutations. At present, most ...
Lakshmi Chandramohan, Paula A Revell
Very little is known about the prevalence and composition of various types of extended-spectrum β-lactamases (ESBL) in pediatric patients. The aims of this study were the following: (i) to determine ...
Ekawut Chankaew, Bunpot Sitthinamsuwan, Prajak Srirabheebhat, Thaweesak Aurboonyawat, Sarun Nunta-aree
De novo aneurysm formation is a rare entity of cerebral aneurysms. The authors describe a 19-year-old man presenting with spontaneous intracerebral hemorrhage of unknown etiology. The initial cerebral...
E Gouache, E Chantier, N Hubert, M-F Rivière
The burden of neonatal bacterial infections continues. They remain a significant cause of death and morbidity, despite recommendations for prevention. The epidemiology of these infections has changed....
Yidan Cui, So Hyun Kim, Hyunseok Kim, Jinki Yeom, Kisung Ko, Woojun Park, Sungsu Park
Extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae poses serious challenges to clinicians because of its resistance to many classes of antibiotics.The mechanism of synergistic activity...
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